Literature DB >> 14573688

A CdtA-CdtC complex can block killing of HeLa cells by Haemophilus ducreyi cytolethal distending toxin.

Kaiping Deng1, Eric J Hansen.   

Abstract

The cytolethal distending toxin (CDT) of Haemophilus ducreyi is comprised of the CdtA, CdtB, and CdtC proteins, with the CdtB protein having demonstrated enzymatic (i.e., DNase) activity. Using a single recombinant Escherichia coli strain with two plasmids individually containing the H. ducreyi cdtA and cdtC genes, we purified a noncovalent CdtA-CdtC complex. Incubation of this CdtA-CdtC complex with HeLa cells blocked killing of these cells by CDT holotoxin. Furthermore, the addition of purified recombinant CdtB to HeLa cells preincubated with the CdtA-CdtC complex resulted in the killing of these human epithelial cells.

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Year:  2003        PMID： 14573688      PMCID： PMC219598          DOI： 10.1128/IAI.71.11.6633-6640.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  33 in total

1.  The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks.

Authors:  V Sert; C Cans; C Tasca; L Bret-Bennis; E Oswald; B Ducommun; J De Rycke
Journal:  Oncogene       Date:  1999-11-04       Impact factor: 9.867

2.  A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein.

Authors:  M Lara-Tejero; J E Galán
Journal:  Science       Date:  2000-10-13       Impact factor: 47.728

3.  CdtA, CdtB, and CdtC form a tripartite complex that is required for cytolethal distending toxin activity.

Authors:  M Lara-Tejero; J E Galán
Journal:  Infect Immun       Date:  2001-07       Impact factor: 3.441

4.  Escherichia coli CdtB mediates cytolethal distending toxin cell cycle arrest.

Authors:  C Elwell; K Chao; K Patel; L Dreyfus
Journal:  Infect Immun       Date:  2001-05       Impact factor: 3.441

5.  The role of different protein components from the Haemophilus ducreyi cytolethal distending toxin in the generation of cell toxicity.

Authors:  A Frisk; M Lebens; C Johansson; H Ahmed; L Svensson; K Ahlman; T Lagergård
Journal:  Microb Pathog       Date:  2001-06       Impact factor: 3.738

6.  DNase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest.

Authors:  C A Elwell; L A Dreyfus
Journal:  Mol Microbiol       Date:  2000-08       Impact factor: 3.501

7.  Investigation of the interaction among the components of the cytolethal distending toxin of Haemophilus ducreyi.

Authors:  K Deng; J L Latimer; D A Lewis; E J Hansen
Journal:  Biochem Biophys Res Commun       Date:  2001-07-20       Impact factor: 3.575

8.  Reconstitution and purification of cytolethal distending toxin of Actinobacillus actinomycetemcomitans.

Authors:  K Saiki; K Konishi; T Gomi; T Nishihara; M Yoshikawa
Journal:  Microbiol Immunol       Date:  2001       Impact factor: 1.955

9.  The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways.

Authors:  X Cortes-Bratti; C Karlsson; T Lagergård; M Thelestam; T Frisan
Journal:  J Biol Chem       Date:  2000-11-13       Impact factor: 5.157

10.  Characterization of a Haemophilus ducreyi mutant deficient in expression of cytolethal distending toxin.

Authors:  M K Stevens; J L Latimer; S R Lumbley; C K Ward; L D Cope; T Lagergard; E J Hansen
Journal:  Infect Immun       Date:  1999-08       Impact factor: 3.441
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  17 in total

1.  Cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol.

Authors:  Aria Eshraghi; Francisco J Maldonado-Arocho; Amandeep Gargi; Marissa M Cardwell; Michael G Prouty; Steven R Blanke; Kenneth A Bradley
Journal:  J Biol Chem       Date:  2010-04-12       Impact factor: 5.157

2.  Cytolethal distending toxin from Shiga toxin-producing Escherichia coli O157 causes irreversible G2/M arrest, inhibition of proliferation, and death of human endothelial cells.

Authors:  Martina Bielaszewska; Bhanu Sinha; Thorsten Kuczius; Helge Karch
Journal:  Infect Immun       Date:  2005-01       Impact factor: 3.441

3.  Introns in the cytolethal distending toxin gene of Actinobacillus actinomycetemcomitans.

Authors:  Kai Soo Tan; Grace Ong; Keang Peng Song
Journal:  J Bacteriol       Date:  2005-01       Impact factor: 3.490

4.  Variation of loop sequence alters stability of cytolethal distending toxin (CDT): crystal structure of CDT from Actinobacillus actinomycetemcomitans.

Authors:  Taro Yamada; Junichi Komoto; Keitarou Saiki; Kiyoshi Konishi; Fusao Takusagawa
Journal:  Protein Sci       Date:  2006-02       Impact factor: 6.725

Review 5.  Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages.

Authors:  Rasika N Jinadasa; Stephen E Bloom; Robert S Weiss; Gerald E Duhamel
Journal:  Microbiology (Reading)       Date:  2011-05-12       Impact factor: 2.777

6.  Involvement of ganglioside GM3 in G(2)/M cell cycle arrest of human monocytic cells induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin.

Authors:  Koji Mise; Sumio Akifusa; Shinobu Watarai; Toshihiro Ansai; Tatsuji Nishihara; Tadamichi Takehara
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

7.  Resistance of human periodontal ligament fibroblasts to the cytolethal distending toxin of Actinobacillus actinomycetemcomitans.

Authors:  Fumio Kanno; Jonathan Korostoff; Alla Volgina; Joseph M DiRienzo
Journal:  J Periodontol       Date:  2005-07       Impact factor: 6.993

8.  Identification of a novel sialic acid transporter in Haemophilus ducreyi.

Authors:  Deborah M B Post; Rachna Mungur; Bradford W Gibson; Robert S Munson
Journal:  Infect Immun       Date:  2005-10       Impact factor: 3.441

9.  Identification of genes involved in the expression of atypical lipooligosaccharide structures from a second class of Haemophilus ducreyi.

Authors:  Deborah M B Post; Robert S Munson; Beth Baker; Huachun Zhong; Joel A Bozue; Bradford W Gibson
Journal:  Infect Immun       Date:  2006-10-09       Impact factor: 3.441

10.  Carbohydrate-binding specificity of the Escherichia coli cytolethal distending toxin CdtA-II and CdtC-II subunits.

Authors:  Leslie A McSweeney; Lawrence A Dreyfus
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441
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