Literature DB >> 1457359

Is liver to lung shunting in colorectal liver metastasis the cause of toxicity following treatment with cytotoxic microsphere aggregates?

T W Hennigan1, S Earlam, T G Allen-Mersh.   

Abstract

Incorporation of cytotoxic drugs into microspheres reduces but does not eliminate systemic toxicity. The extent of liver to lung shunt was measured in 26 patients with colorectal liver metastasis. Liver to lung shunting correlated with proportion of liver replacement but did not exceed 4.4% and therefore is unlikely to cause systemic toxicity.

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Year:  1992        PMID： 1457359      PMCID： PMC1978010          DOI： 10.1038/bjc.1992.429

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  9 in total

1.  Cytotoxic-loaded albumin microspheres: a novel approach to regional chemotherapy.

Authors:  C S McArdle; H Lewi; D Hansell; D J Kerr; J McKillop; N Willmott
Journal:  Br J Surg       Date:  1988-02       Impact factor: 6.939

2.  Pharmacokinetics of intra-arterial mitomycin C with or without degradable starch microspheres (DSM) in the treatment of non-resectable liver cancer.

Authors:  M Andersson; K F Aronsen; C Balch; L Domellöf; S Eksborg; L O Hafström; S B Howell; R Kåresen; J Midander; H Teder
Journal:  Acta Oncol       Date:  1989       Impact factor: 4.089

3.  Pilot study of intra-arterial floxuridine, mitomycin and doxorubicin in combination with degradable starch microspheres to treat primary and metastatic tumors of the liver.

Authors:  C E Pfeifle; S B Howell; J J Bookstein
Journal:  Cancer Drug Deliv       Date:  1985

4.  Regional chemotherapy for colorectal liver metastases: a phase II evaluation of targeted hepatic arterial 5-fluorouracil for colorectal liver metastases.

Authors:  J A Goldberg; D J Kerr; N Wilmott; J H McKillop; C S McArdle
Journal:  Br J Surg       Date:  1990-11       Impact factor: 6.939

5.  Improved regional selectivity of hepatic arterial BCNU with degradable microspheres.

Authors:  S Dakhil; W Ensminger; K Cho; J Niederhuber; K Doan; R Wheeler
Journal:  Cancer       Date:  1982-08-15       Impact factor: 6.860

6.  Reduced toxicity of adriamycin by incorporation into ion exchange microspheres: a therapeutic study using a rat liver tumour model.

Authors:  J P Codde; M A Burton; D K Kelleher; S G Archer; B N Gray
Journal:  Anticancer Res       Date:  1990 Nov-Dec       Impact factor: 2.480

7.  Target organ disposition and plasma pharmacokinetics of doxorubicin incorporated into albumin microspheres after intrarenal arterial administration.

Authors:  D J Kerr; N Willmott; J H McKillop; J Cummings; H J Lewi; C S McArdle
Journal:  Cancer       Date:  1988-09-01       Impact factor: 6.860

8.  Ultrastructural morphometry of cultivated smooth muscle cells from normotensive and hypertensive rats.

Authors:  J Grünwald; W Wischer
Journal:  Exp Pathol       Date:  1985

9.  Improved regional selectivity of hepatic arterial mitomycin by starch microspheres.

Authors:  J W Gyves; W D Ensminger; D VanHarken; J Niederhuber; P Stetson; S Walker
Journal:  Clin Pharmacol Ther       Date:  1983-08       Impact factor: 6.875
  9 in total
  2 in total

1.  Continuous angiotensin II infusion increases tumour: normal blood flow ratio in colo-rectal liver metastases.

Authors:  D Burke; M M Davies; J Zweit; M A Flower; R J Ott; M J Dworkin; C Glover; V R McCready; P Carnochan; T G Allen-Mersh
Journal:  Br J Cancer       Date:  2001-11-30       Impact factor: 7.640

2.  Spontaneous intracardiac microcavitations in a patient with a colonic carcinoma.

Authors:  Alexander Graf; Christian Steffen; Sonia Frick
Journal:  BMJ Case Rep       Date:  2019-09-05
  2 in total

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