| Literature DB >> 14572867 |
Marisa A Nogueira1, Eva G Magalhães, Aderbal F Magalhães, Débora N Biloti, Antonio Laverde, Francisco B T Pessine, João E Carvalho, Luciana K Kohn, Márcia A Antônio, Anita J Marsaioli.
Abstract
A novel series of eight dibenzoylmethane derivatives having both sunscreen and cytotoxic activity has been obtained by derivatizing commercial dibenzoyl methanes. Four human cancer cell lines (MCF 7 (breast), NCI ADR (breast expressing the multidrug resistance phenotype), NCI 460 (lung) and UACC 62 (melanoma)) were used for the cytotoxic assay. Eight among the 19 dibenzoylmethane derivatives showed cytotoxicity against these four cell lines. Absorption spectroscopies revealed that these compounds can be used as sunscreens against UV radiation.Entities:
Mesh：
Substances：
Year: 2003 PMID： 14572867 DOI： 10.1016/s0014-827x(03)00195-2
Source DB: PubMed Journal: Farmaco ISSN： 0014-827X