OBJECTIVES: To determine the association between psychosocial characteristics and time to relapse in patients with inactive ulcerative colitis. METHODS: Sixty patients with clinically and endoscopically inactive ulcerative colitis were followed for 1 yr, or less if they relapsed. Demographic, psychosocial, and clinical data were obtained. Stressful life events (Psychiatric Epidemiology Research Interview Life Events Scale), psychological distress (Symptom Checklist-90R), and perceived stress (Perceived Stress Scale) were recorded monthly by self-report. Multivariate time-dependent Cox regression was used to identify the independent determinants of earlier time to clinical relapse. RESULTS: The patients' mean age was 39 yr (SD = 9.4), 37 (62%) were female, and 22 (37%) relapsed during the 1-yr follow-up. Univariate Cox regression indicated a weak association between number of stressful events in the preceding month and time to relapse (p = 0.09). This association strengthened in multivariate analysis (p = 0.02, hazard ratio = 1.26 per event, 95% CI = 1.04-1.53) after adjustment for significant covariates. CONCLUSIONS: After controlling for demographic and clinical variables, more recent stressful events were associated with earlier time to relapse. These findings, which support a biopsychosocial model of disease, might help clinicians identify patients who might benefit from more intensive maintenance medical therapy and behavioral medicine interventions to reduce stress and improve coping.
OBJECTIVES: To determine the association between psychosocial characteristics and time to relapse in patients with inactive ulcerative colitis. METHODS: Sixty patients with clinically and endoscopically inactive ulcerative colitis were followed for 1 yr, or less if they relapsed. Demographic, psychosocial, and clinical data were obtained. Stressful life events (Psychiatric Epidemiology Research Interview Life Events Scale), psychological distress (Symptom Checklist-90R), and perceived stress (Perceived Stress Scale) were recorded monthly by self-report. Multivariate time-dependent Cox regression was used to identify the independent determinants of earlier time to clinical relapse. RESULTS: The patients' mean age was 39 yr (SD = 9.4), 37 (62%) were female, and 22 (37%) relapsed during the 1-yr follow-up. Univariate Cox regression indicated a weak association between number of stressful events in the preceding month and time to relapse (p = 0.09). This association strengthened in multivariate analysis (p = 0.02, hazard ratio = 1.26 per event, 95% CI = 1.04-1.53) after adjustment for significant covariates. CONCLUSIONS: After controlling for demographic and clinical variables, more recent stressful events were associated with earlier time to relapse. These findings, which support a biopsychosocial model of disease, might help clinicians identify patients who might benefit from more intensive maintenance medical therapy and behavioral medicine interventions to reduce stress and improve coping.
Authors: David J van Westerloo; Goda Choi; Ester C Löwenberg; Jasper Truijen; Alex F de Vos; Erik Endert; Joost C M Meijers; Lu Zhou; Manuel P F L Pereira; Karla C S Queiroz; Sander H Diks; Marcel Levi; Maikel P Peppelenbosch; Tom van der Poll Journal: Mol Med Date: 2010-12-10 Impact factor: 6.354
Authors: Venkata Subhash Gorrepati; Sanjay Yadav; August Stuart; Walter Koltun; Evangelos Messaris; Emmanuelle D Williams; Matthew D Coates Journal: Int J Colorectal Dis Date: 2018-06-29 Impact factor: 2.571
Authors: Anilga Tabibian; James H Tabibian; Linda J Beckman; Laura L Raffals; Konstantinos A Papadakis; Sunanda V Kane Journal: Dig Dis Sci Date: 2015-01-06 Impact factor: 3.199
Authors: Arturo L Colón; José L M Madrigal; Luis A Menchén; María A Moro; Ignacio Lizasoain; Pedro Lorenzo; Juan C Leza Journal: Dig Dis Sci Date: 2004-10 Impact factor: 3.199