Literature DB >> 14572290

Synthetic studies toward FR182877. Remarkable solvent effect in the vinylogous morita-baylis-hillman cyclization.

Joey L Methot1, William R Roush.   

Abstract

[reaction: see text]. The intramolecular vinylogous Morita-Baylis-Hillman reaction was explored to access the central cyclopentane ring of FR182877. The reaction manifold and product distribution is strikingly solvent and substrate dependent.

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Year:  2003        PMID： 14572290     DOI： 10.1021/ol0357550

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Quasi-Biomimetic Ring Contraction Catalyzed by a Cysteine-Based Nucleophile: Total Synthesis of Sch-642305, Some Analogs and their Putative anti-HIV Activities.

Authors:  Alpay Dermenci; Philipp S Selig; Robert A Domaoal; Krasimir A Spasov; Karen S Anderson; Scott J Miller
Journal:  Chem Sci       Date:  2011-08-01       Impact factor: 9.825

2.  Remarkable phosphine-effect on the intramolecular aldol reactions of unsaturated 1,5-diketones: highly regioselective synthesis of cross-conjugated dienones.

Authors:  Reema K Thalji; William R Roush
Journal:  J Am Chem Soc       Date:  2005-12-07       Impact factor: 15.419

3.  Intramolecular Diels-Alder reactions of siloxacyclopentene constrained trienes.

Authors:  Geoff T Halvorsen; William R Roush
Journal:  Org Lett       Date:  2007-05-05       Impact factor: 6.005

4.  Lewis acid-catalyzed conjugate additions of silyloxyallenes: a selective solution to the intermolecular Rauhut-Currier problem.

Authors:  Troy E Reynolds; Michael S Binkley; Karl A Scheidt
Journal:  Org Lett       Date:  2008-05-14       Impact factor: 6.005
  4 in total

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