Literature DB >> 14570037

Cannabinoids: potential anticancer agents.

Manuel Guzmán1.   

Abstract

Cannabinoids - the active components of Cannabis sativa and their derivatives - exert palliative effects in cancer patients by preventing nausea, vomiting and pain and by stimulating appetite. In addition, these compounds have been shown to inhibit the growth of tumour cells in culture and animal models by modulating key cell-signalling pathways. Cannabinoids are usually well tolerated, and do not produce the generalized toxic effects of conventional chemotherapies. So, could cannabinoids be used to develop new anticancer therapies?

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Year:  2003        PMID： 14570037     DOI： 10.1038/nrc1188

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  180 in total

1.  N-acyl taurines are anti-proliferative in prostate cancer cells.

Authors:  Vicky Chatzakos; Katharina Slätis; Tatjana Djureinovic; Thomas Helleday; Mary C Hunt
Journal:  Lipids       Date:  2011-12-11       Impact factor: 1.880

2.  Endocannabinoid-like N-arachidonoyl serine is a novel pro-angiogenic mediator.

Authors:  X Zhang; Y Maor; J F Wang; G Kunos; J E Groopman
Journal:  Br J Pharmacol       Date:  2010-08       Impact factor: 8.739

3.  Impaired NFAT and NFκB activation are involved in suppression of CD40 ligand expression by Δ(9)-tetrahydrocannabinol in human CD4(+) T cells.

Authors:  Thitirat Ngaotepprutaram; Barbara L F Kaplan; Norbert E Kaminski
Journal:  Toxicol Appl Pharmacol       Date:  2013-08-30       Impact factor: 4.219

Review 4.  The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids.

Authors:  Roger G Pertwee
Journal:  AAPS J       Date:  2005-10-24       Impact factor: 4.009

5.  Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis.

Authors:  Anju Preet; Zahida Qamri; Mohd W Nasser; Anil Prasad; Konstantin Shilo; Xianghong Zou; Jerome E Groopman; Ramesh K Ganju
Journal:  Cancer Prev Res (Phila)       Date:  2010-11-19

6.  Cannabinoids attenuate cancer pain and proliferation in a mouse model.

Authors:  Negin Saghafi; David K Lam; Brian L Schmidt
Journal:  Neurosci Lett       Date:  2010-11-19       Impact factor: 3.046

7.  Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells.

Authors:  Sean D McAllister; Calvin Chan; Ryan J Taft; Tri Luu; Mary E Abood; Dan H Moore; Ken Aldape; Garret Yount
Journal:  J Neurooncol       Date:  2005-08       Impact factor: 4.130

8.  Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy.

Authors:  Partha Mukhopadhyay; Mohanraj Rajesh; Hao Pan; Vivek Patel; Bani Mukhopadhyay; Sándor Bátkai; Bin Gao; György Haskó; Pál Pacher
Journal:  Free Radic Biol Med       Date:  2009-12-04       Impact factor: 7.376

Review 9.  The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities.

Authors:  Tamás Bíró; Balázs I Tóth; György Haskó; Ralf Paus; Pál Pacher
Journal:  Trends Pharmacol Sci       Date:  2009-07-14       Impact factor: 14.819

Review 10.  The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.

Authors:  R G Pertwee
Journal:  Br J Pharmacol       Date:  2007-09-10       Impact factor: 8.739
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