Literature DB >> 14568403

Biodegradable electrospun fibers for drug delivery.

Jing Zeng1, Xiaoyi Xu, Xuesi Chen, Qizhi Liang, Xinchao Bian, Lixin Yang, Xiabin Jing.   

Abstract

The influences of surfactants and medical drugs on the diameter size and uniformity of electrospun poly(L-lactic acid) (PLLA) fibers were examined by adding various surfactants (cationic, anionic, and nonionic) and typical drugs into the PLLA solution. Significant diameter reduction and uniformity improvement were observed. It was shown that the drugs were capsulated inside of the fibers and the drug release in the presence of proteinase K followed nearly zero-order kinetics due to the degradation of the PLLA fibers. Such ultrafine fiber mats containing drugs may find clinical applications in the future.

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Year:  2003        PMID： 14568403     DOI： 10.1016/s0168-3659(03)00372-9

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  89 in total

1.  Fabrication and evaluation of electrospun collagen/poly(N-isopropyl acrylamide)/chitosan mat as blood-contacting biomaterials for drug delivery.

Authors:  Saravanabhavan Shanmuga Sundar; Dharmalingam Sangeetha
Journal:  J Mater Sci Mater Med       Date:  2012-04-03       Impact factor: 3.896

Review 2.  Recent development of polymer nanofibers for biomedical and biotechnological applications.

Authors:  Yanzhong Zhang; Chwee Teck Lim; Seeram Ramakrishna; Zheng-Ming Huang
Journal:  J Mater Sci Mater Med       Date:  2005-10       Impact factor: 3.896

Review 3.  The role of electrospinning in the emerging field of nanomedicine.

Authors:  S Y Chew; Y Wen; Y Dzenis; K W Leong
Journal:  Curr Pharm Des       Date:  2006       Impact factor: 3.116

Review 4.  Functional electrospun nanofibrous scaffolds for biomedical applications.

Authors:  Dehai Liang; Benjamin S Hsiao; Benjamin Chu
Journal:  Adv Drug Deliv Rev       Date:  2007-08-25       Impact factor: 15.470

5.  Study of release speeds and bacteria inhibiting capabilities of drug delivery membranes fabricated via electrospinning by observing bacteria growth curves.

Authors:  Yao Nan Lin; Kai Ming Chang; Shiang Cheng Jeng; Ping Yu Lin; Ray Quen Hsu
Journal:  J Mater Sci Mater Med       Date:  2011-02-03       Impact factor: 3.896

Review 6.  Emerging Roles of Electrospun Nanofibers in Cancer Research.

Authors:  Shixuan Chen; Sunil Kumar Boda; Surinder K Batra; Xiaoran Li; Jingwei Xie
Journal:  Adv Healthc Mater       Date:  2017-12-06       Impact factor: 9.933

7.  Mussel-inspired protein-mediated surface functionalization of electrospun nanofibers for pH-responsive drug delivery.

Authors:  J Jiang; J Xie; B Ma; D E Bartlett; A Xu; C-H Wang
Journal:  Acta Biomater       Date:  2013-11-25       Impact factor: 8.947

8.  Mechanical properties of single electrospun drug-encapsulated nanofibres.

Authors:  Sing Yian Chew; Todd C Hufnagel; Chwee Teck Lim; Kam W Leong
Journal:  Nanotechnology       Date:  2006-08-14       Impact factor: 3.874

9.  Tunable Release of Multiclass Anti-HIV Drugs that are Water-Soluble and Loaded at High Drug Content in Polyester Blended Electrospun Fibers.

Authors:  Daniel Carson; Yonghou Jiang; Kim A Woodrow
Journal:  Pharm Res       Date:  2015-08-19       Impact factor: 4.200

Review 10.  Electrospun Fibers for Spinal Cord Injury Research and Regeneration.

Authors:  Nicholas J Schaub; Christopher D Johnson; Blair Cooper; Ryan J Gilbert
Journal:  J Neurotrauma       Date:  2016-03-30       Impact factor: 5.269
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