| Literature DB >> 14568348 |
Akihito Okabe1, Masamichi Yokokura, Hiroki Toyoda, Chigusa Shimizu-Okabe, Koji Ohno, Kohji Sato, Atsuo Fukuda.
Abstract
In a rat kindling model, we examined expression patterns of NKCC1, KCC1, KCC2, and CLC-2. In the dentate granule cell layer, there was an activity-dependent increase in NKCC1 mRNA but significant decreases in KCC1 and CLC-2 mRNAs. In addition, CLC-2 mRNA expression was markedly decreased in CA1 pyramidal layer. These results suggest that an increase in [Cl-]i and a resultant reduction in GABAergic inhibition may occur in hippocampus of epileptic rats.Entities:
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Year: 2003 PMID： 14568348 DOI： 10.1016/s0006-8993(03)03528-5
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252