| Literature DB >> 14567909 |
Abstract
Many integral proteins of the ribosome also carry out extra-ribosomal functions as independent polypeptides, raising questions as to their evolutionary derivation. In this issue of Cell, Mazumder et al. report a surprising new twist in the dual life of these molecules: as part of a cellular response to interferon, a large-subunit protein dramatically exits the ribosome to bind and inhibit the translation of a specific mRNA.Mesh:
Substances:
Year: 2003 PMID: 14567909 DOI: 10.1016/s0092-8674(03)00804-3
Source DB: PubMed Journal: Cell ISSN: 0092-8674 Impact factor: 41.582