Literature DB >> 14567883

Heritability and candidate genes for endometriosis.

Joe Leigh Simpson1, Farideh Bischoff.   

Abstract

Endometriosis is inherited in polygenic/multifactorial fashion, with recurrence risks of 5-7% for first-degree relatives. The current task is to determine the number and location of causative genes. This review initially supports the basis for polygenic/multifactorial inheritance and then outlines genome-wide strategies for identifying causative genes. Potential candidate genes are surveyed, and discrepant results emphasized. Finally, a hypothesis for endometriosis, having a multi-step pathogenesis analogous to the pathogenesis of neoplasia, is considered.

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Year:  2003        PMID： 14567883     DOI： 10.1016/s1472-6483(10)61746-4

Source DB:  PubMed          Journal:  Reprod Biomed Online        ISSN： 1472-6483            Impact factor:   3.828


  3 in total

1.  Risk Factors for Endometriosis in a German Case-Control Study.

Authors:  S Burghaus; P Klingsiek; P A Fasching; A Engel; L Häberle; P L Strissel; M Schmidt; K Jonas; J D Strehl; A Hartmann; J Lermann; A Boosz; F C Thiel; A Müller; M W Beckmann; S P Renner
Journal:  Geburtshilfe Frauenheilkd       Date:  2011-12       Impact factor: 2.915

2.  Endometrial-peritoneal interactions during endometriotic lesion establishment.

Authors:  M Louise Hull; Claudia Rangel Escareno; Jane M Godsland; John R Doig; Claire M Johnson; Stephen C Phillips; Stephen K Smith; Simon Tavaré; Cristin G Print; D Stephen Charnock-Jones
Journal:  Am J Pathol       Date:  2008-08-07       Impact factor: 4.307

3.  No evidence for genetic association with the let-7 microRNA-binding site or other common KRAS variants in risk of endometriosis.

Authors:  Hien T T Luong; Dale R Nyholt; Jodie N Painter; Brett Chapman; Stephen Kennedy; Susan A Treloar; Krina T Zondervan; Grant W Montgomery
Journal:  Hum Reprod       Date:  2012-09-25       Impact factor: 6.918
  3 in total

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