K Sato1, M Kato, T Yoshimoto. 1. Department of Neuroanesthesia, Kohnan Hospital, 4-20-1 Nagamachi-minami, Sendai 982-8523, Japan.
Abstract
PURPOSE: To clarify the clinical significance of QT dispersion and the longest QT intervals (L-QTc) in patients with subarachnoid hemorrhage (SAH). METHODS: ECGs, clinical features, and laboratory data were analyzed in 38 patients with SAH (R) and 30 with unruptured cerebral aneurysms (U). Standard 12-lead ECGs obtained on admission were analyzed manually, and the longest QT interval (L-QTc) and the QT dispersion (difference between longest and shortest QTc) were compared between groups. RESULTS: There were no differences between groups R and U in age, sex, or location of aneurysms. The QT dispersion and L-QTc were greater in R than in U (109 +/- 49 vs 64 +/- 21 ms and 503 +/- 63 vs 435 +/- 38 ms, respectively; P < 0.01). The QT dispersion and L-QTc were longer in patients with premature ventricular contractions (PVCs) than in patients without PVCs (185 +/- 30 vs 85 +/- 41 ms and 586 +/- 47 vs 467 +/- 59 ms, respectively; P < 0.01). There were positive correlations between QT dispersion or L-QTc and preoperative Hunt and Hess grade (rs = 0.560 and rs = 0.615, respectively; P < 0.01). QT dispersion and L-QTc tended to correlate negatively with serum K(+) (r = -0.365 and r = -0.376, respectively). CONCLUSION: QT dispersion in patients with SAH is prolonged, especially in high-grade cases.
PURPOSE: To clarify the clinical significance of QT dispersion and the longest QT intervals (L-QTc) in patients with subarachnoid hemorrhage (SAH). METHODS: ECGs, clinical features, and laboratory data were analyzed in 38 patients with SAH (R) and 30 with unruptured cerebral aneurysms (U). Standard 12-lead ECGs obtained on admission were analyzed manually, and the longest QT interval (L-QTc) and the QT dispersion (difference between longest and shortest QTc) were compared between groups. RESULTS: There were no differences between groups R and U in age, sex, or location of aneurysms. The QT dispersion and L-QTc were greater in R than in U (109 +/- 49 vs 64 +/- 21 ms and 503 +/- 63 vs 435 +/- 38 ms, respectively; P < 0.01). The QT dispersion and L-QTc were longer in patients with premature ventricular contractions (PVCs) than in patients without PVCs (185 +/- 30 vs 85 +/- 41 ms and 586 +/- 47 vs 467 +/- 59 ms, respectively; P < 0.01). There were positive correlations between QT dispersion or L-QTc and preoperative Hunt and Hess grade (rs = 0.560 and rs = 0.615, respectively; P < 0.01). QT dispersion and L-QTc tended to correlate negatively with serum K(+) (r = -0.365 and r = -0.376, respectively). CONCLUSION: QT dispersion in patients with SAH is prolonged, especially in high-grade cases.
Authors: Yitzchok S Lederman; Clotilde Balucani; Jason Lazar; Leah Steinberg; James Gugger; Steven R Levine Journal: J Stroke Cerebrovasc Dis Date: 2014-10-03 Impact factor: 2.136
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