Literature DB >> 14565451

Novel method for the covalent immobilization of oligonucleotides via Diels-Alder bioconjugation.

Hallie A Latham-Timmons1, Andreas Wolter, J Shawn Roach, Rubina Giare, Michael Leuck.   

Abstract

The synthesis of cyclohexadiene and maleimide derivatives and their use for the functionalization of oligonucleotides and the coating of glass surfaces is reported. A method for the covalent attachment of diene or maleimide modified oligonucleotides to the coated glass surfaces via aqueous Diels-Alder reactions is presented.

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Year:  2003        PMID： 14565451     DOI： 10.1081/NCN-120023019

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  5 in total

Review 1.  Bioorthogonal chemistry: recent progress and future directions.

Authors:  Reyna K V Lim; Qing Lin
Journal:  Chem Commun (Camb)       Date:  2010-01-21       Impact factor: 6.222

2.  Chemoselective immobilization of biomolecules through aqueous Diels-Alder and PEG chemistry.

Authors:  Xue-Long Sun; Liuchun Yang; Elliot L Chaikof
Journal:  Tetrahedron Lett       Date:  2008       Impact factor: 2.415

3.  Bioorthogonal Chemistry-A Covalent Strategy for the Study of Biological Systems.

Authors:  Reyna K V Lim; Qing Lin
Journal:  Sci China Chem       Date:  2010-01-01       Impact factor: 9.445

4.  Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.

Authors:  Melissa L Blackman; Maksim Royzen; Joseph M Fox
Journal:  J Am Chem Soc       Date:  2008-09-18       Impact factor: 15.419

5.  Diels-Alder cycloadditions in water for the straightforward preparation of peptide-oligonucleotide conjugates.

Authors:  Vicente Marchán; Samuel Ortega; Daniel Pulido; Enrique Pedroso; Anna Grandas
Journal:  Nucleic Acids Res       Date:  2006-02-14       Impact factor: 16.971
  5 in total

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