Literature DB >> 14565368

Synthesis of a base-protected alpha-L-LNA guanine nucleoside.

Gilles Gaubert1, Jesper Wengel.   

Abstract

Synthesis of (1R,3R,4S,7R)-7-hydroxy-1-hydroxymethyl-3-(2-N-isobutyroylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane (12), a protected alpha-L-LNA guanine nucleoside, has been accomplished using a convergent synthetic strategy starting from 1,2-di-O-acetylfuranose 4.

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Year:  2003        PMID: 14565368     DOI: 10.1081/NCN-120022824

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  1 in total

1.  Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides.

Authors:  Torben Højland; Rakesh N Veedu; Birte Vester; Jesper Wengel
Journal:  Artif DNA PNA XNA       Date:  2012 Jan-Mar
  1 in total

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