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Literature DB >> 14565339

Nuclease stability of LNA oligonucleotides and LNA-DNA chimeras.

Miriam Frieden¹, Henrik F Hansen, Troels Koch.

Abstract

The stabilizing properties of LNA and alpha-L-LNA oligonucleotides against endo- and 3'-exonucleases have been evaluated.

Entities: Chemical

Mesh：

Substances：

Year: 2003 PMID： 14565339 DOI： 10.1081/NCN-120022731

Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381

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Cited

16 in total

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Review 4. DNA triple helices: biological consequences and therapeutic potential.

Authors: Aklank Jain; Guliang Wang; Karen M Vasquez
Journal: Biochimie Date: 2008-02-21 Impact factor: 4.079

5. Inhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA.

Authors: Randall L Beane; Rosalyn Ram; Sylvie Gabillet; Khalil Arar; Brett P Monia; David R Corey
Journal: Biochemistry Date: 2007-05-31 Impact factor: 3.162

6. Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.

Authors: Ellen Marie Straarup; Niels Fisker; Maj Hedtjärn; Marie W Lindholm; Christoph Rosenbohm; Vibeke Aarup; Henrik Frydenlund Hansen; Henrik Ørum; Jens B Rode Hansen; Troels Koch
Journal: Nucleic Acids Res Date: 2010-07-08 Impact factor: 16.971

Nuclease stability of LNA oligonucleotides and LNA-DNA chimeras.

1. A highly sensitive and selective signal-on strategy for microRNA quantification.

2. A direct comparison of anti-microRNA oligonucleotide potency.

Review 3. DNA and RNA derivatives to optimize distribution and delivery.

Review 4. DNA triple helices: biological consequences and therapeutic potential.

5. Inhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA.

6. Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.

7. Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides.

8. Design of LNA probes that improve mismatch discrimination.

9. Improved targeting of miRNA with antisense oligonucleotides.

10. Development of one-step quantitative reverse transcription PCR for the rapid detection of flaviviruses.