Literature DB >> 14565303

Synthesis of 4'-C-ethynyl and 4'-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity.

Satoru Kohgo1, Kohei Yamada, Kenji Kitano, Shinji Sakata, Hiroyuki Hayakawa, Daisuke Nameki, Eiichi Kodama, Masao Matsuoka, Hiroaki Mitsuya, Hiroshi Ohrui.   

Abstract

Purine 2'-deoxynucleosides bearing an ethynyl or a cyano group at C-4' of the sugar moiety were synthesized from the corresponding 2'-deoxynucleosides. These compounds exhibited very potent anti-HIV activity, and remained active against drug resistant HIV strains.

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Year:  2003        PMID： 14565303     DOI： 10.1081/NCN-120022678

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  2 in total

1.  Oral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaque.

Authors:  Cheryl A Stoddart; Sofiya A Galkina; Pheroze Joshi; Galina Kosikova; Mary E Moreno; Jose M Rivera; Barbara Sloan; Aaron B Reeve; Stefan G Sarafianos; Michael Murphey-Corb; Michael A Parniak
Journal:  Antimicrob Agents Chemother       Date:  2015-05-04       Impact factor: 5.191

2.  Response of simian immunodeficiency virus to the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine in vitro and in vivo.

Authors:  Michael Murphey-Corb; Premeela Rajakumar; Heather Michael; Julia Nyaundi; Peter J Didier; Aaron B Reeve; Hiroaki Mitsuya; Stefan G Sarafianos; Michael A Parniak
Journal:  Antimicrob Agents Chemother       Date:  2012-06-19       Impact factor: 5.191
  2 in total

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