Literature DB >> 14565271

Efficient synthesis of 8-thiosubstituted guanine derivatives as potential tools for biochemical and biological studies.

Martins Ikaunieks1, Marina Madre.   

Abstract

A method for the selective introduction of the N2-(dimethylamino)methylene group into 8-thio-9-(2-hydroxyethoxymethyl)guanine (1) has been developed. The effect of the N2-amidine protection on the S-alkylation of 1 was studied.

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Year:  2003        PMID: 14565271     DOI: 10.1081/NCN-120022627

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  1 in total

1.  Novel N7- and N1-substituted cGMP derivatives are potent activators of cyclic nucleotide-gated channels.

Authors:  Timothy Strassmaier; Jeffrey W Karpen
Journal:  J Med Chem       Date:  2007-08-01       Impact factor: 7.446

  1 in total

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