| Literature DB >> 14565270 |
Vladimir N Barai1, Anatoli I Zinchenko, Ludmilla A Eroshevskaya, Elena V Zhernosek, Jan Balzarini, Erik De Clercq, Igor A Mikhailopulo.
Abstract
9-(3-Deoxy-beta-D-erythro-pentofuranosyl)-2,6-diaminopurine (2) was synthesized by an enzymatic transglycosylation of 2,6-diaminopurine using 3'-deoxycytidine (1) as a donor of the sugar moiety. Nucleoside 2 was transformed to 3'-deoxy guanosine (3), 9-(3-deoxy-beta-D-erythro-pentofuranosyl)-2-amino-6-oxopurine (3'-deoxyisoguanosine; 4), and 9-(3-deoxy-beta-D-erythro-pentofuranosyl)-2-fluoroadenine (5). Compounds 2-5 were evaluated for their anti-HIV activity.Entities:
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Year: 2003 PMID： 14565270 DOI： 10.1081/NCN-120022626
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381