| Literature DB >> 14565269 |
Abdalla E A Hassan1, William B Parker, Paula W Allan, John A Montgomery, John A Secrist.
Abstract
A selective metalation at the 6-CH3 over C-8 of 6-methylpurine derivative 6 was observed with softer counter cation (Na+ or K+) of the base, while the harder Li+ showed no selectivity. In the presence of N-fluorobenzenesulfonamide (NFSI), this property was utilized for the synthesis of 6-fluoromethylpurine derivatives 4 and 5 as potential toxins for suicide gene therapy.Entities:
Mesh：
Substances：
Year: 2003 PMID： 14565269 DOI： 10.1081/NCN-120022625
Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381