Literature DB >> 14565243

A role for oligonucleotide-based RNA-knock down technologies in functional genomics.

Gabriele Dorn1, Jonathan Hall, Dieter Hüsken, Jörg Lange, Pierre Martin, Francois Natt, William L Wishart, Jan Weiler.   

Abstract

Functional genomics is inundating the pharmaceutical industry with large numbers of potential gene targets from several sources such as gene expression profiling experiments (DNA microchips, proteomics) or database mining. Oligonucleotide-based RNA-knock down technologies such as antisense or RNA interference can aid in the filtering and prioritization of target candidates in the drug discovery process.

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Year:  2003        PMID: 14565243     DOI: 10.1081/NCN-120021970

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  1 in total

1.  REM sleep changes in rats induced by siRNA-mediated orexin knockdown.

Authors:  Lichao Chen; Mahesh M Thakkar; Stuart Winston; Yunren Bolortuya; Radhika Basheer; Robert W McCarley
Journal:  Eur J Neurosci       Date:  2006-10       Impact factor: 3.386

  1 in total

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