Literature DB >> 14564700

Conversion of cholesterol injected into man to cholestanol via a 3-ketonic intermediate.

R S Rosenfeld1, B Zumoff, L Hellman.   

Abstract

Cholesterol-3-(3)H,4-(14)C was injected intravenously in man and its transformation to cholestanol was studied. From the (3)H: (14)C ratios in cholestanol isolated from blood, evidence for the participation of a ketonic intermediate in the conversion was obtained. In a second subject given cholestanol-3-(3)H,4-(14)C the (3)H: (14)C ratios in blood sterols remained unchanged for as long as 1 wk after the injection, which showed that cholestanol did not lose tritium by interconversion with cholestanone.

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Year:  1967        PMID: 14564700

Source DB:  PubMed          Journal:  J Lipid Res        ISSN: 0022-2275            Impact factor:   5.922


  9 in total

1.  Isolation and identification of cholesterol -oxide and other minor sterols in human serum.

Authors:  M F Gray; T D Lawrie; C J Brooks
Journal:  Lipids       Date:  1971-11       Impact factor: 1.880

2.  Steroids in bovine muscle and adipose tissue.

Authors:  C Tu; W D Powrie; O Fennema
Journal:  Lipids       Date:  1969-09       Impact factor: 1.880

3.  Biosynthesis of 5 -cholestan-3 -ol in cerebrotendinous xanthomatosis.

Authors:  G Salen; A Polito
Journal:  J Clin Invest       Date:  1972-01       Impact factor: 14.808

4.  Sterol synthesis in the human arterial intima.

Authors:  A V Chorbanian
Journal:  J Clin Invest       Date:  1968-03       Impact factor: 14.808

5.  The metabolism of cholestanol, cholesterol, and bile acids in cerebrotendinous xanthomatosis.

Authors:  G Salen; S M Grundy
Journal:  J Clin Invest       Date:  1973-11       Impact factor: 14.808

Review 6.  [Atypical bile acids (author's transl)].

Authors:  P Back
Journal:  Klin Wochenschr       Date:  1980-01-15

7.  The different effects on the serum lipids and fecal steroids of high carbohydrate diets given orally or intravenously.

Authors:  L DenBesten; R H Reyna; W E Connor; L D Stegink
Journal:  J Clin Invest       Date:  1973-06       Impact factor: 14.808

8.  Effects of cholestanol feeding and cholestyramine treatment on the tissue sterols in the rabbit.

Authors:  M S Buchmann; O P Clausen
Journal:  Lipids       Date:  1986-12       Impact factor: 1.880

9.  A novel pathway for biosynthesis of cholestanol with 7 alpha-hydroxylated C27-steroids as intermediates, and its importance for the accumulation of cholestanol in cerebrotendinous xanthomatosis.

Authors:  S Skrede; I Björkhem; M S Buchmann; G Hopen; O Fausa
Journal:  J Clin Invest       Date:  1985-02       Impact factor: 14.808

  9 in total

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