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Literature DB >> 14561696

What brings pericytes to tumor vessels?

Abstract

Paracrine signaling via platelet-derived growth factor B (PDGFB), expressed by endothelial cells, and its receptor PDGFR-beta, expressed by pericytes, plays a central role in blood vessel maturation. A new study (see the related article beginning on page 1142) reveals that it is not just the presence of PDGFB, but how it is presented to pericytes, that determines the quality of the endothelium-pericyte interaction.

Entities: Disease Gene

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Year: 2003 PMID： 14561696 PMCID： PMC213497 DOI： 10.1172/JCI20087

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

17 in total

Review 1. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.

Authors: R K Jain
Journal: Nat Med Date: 2001-09 Impact factor: 53.440

2. Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival.

Authors: N Reinmuth; W Liu; Y D Jung; S A Ahmad; R M Shaheen; F Fan; C D Bucana; G McMahon; G E Gallick; L M Ellis
Journal: FASEB J Date: 2001-05 Impact factor: 5.191

Review 3. Angiogenesis in health and disease.

Authors: Peter Carmeliet
Journal: Nat Med Date: 2003-06 Impact factor: 53.440

4. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.

Authors: E B Brown; R B Campbell; Y Tsuzuki; L Xu; P Carmeliet; D Fukumura; R K Jain
Journal: Nat Med Date: 2001-07 Impact factor: 53.440

5. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors.

Authors: Shunichi Morikawa; Peter Baluk; Toshiyuki Kaidoh; Amy Haskell; Rakesh K Jain; Donald M McDonald
Journal: Am J Pathol Date: 2002-03 Impact factor: 4.307

6. Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.

Authors: A Kadambi; C Mouta Carreira; C O Yun; T P Padera; D E Dolmans; P Carmeliet; D Fukumura; R K Jain
Journal: Cancer Res Date: 2001-03-15 Impact factor: 12.701

7. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors.

Authors: Gabriele Bergers; Steven Song; Nicole Meyer-Morse; Emily Bergsland; Douglas Hanahan
Journal: J Clin Invest Date: 2003-05 Impact factor: 14.808

8. Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching.

Authors: Rachel C Chambers; Patricia Leoni; Naftali Kaminski; Geoffrey J Laurent; Renu A Heller
Journal: Am J Pathol Date: 2003-02 Impact factor: 4.307

9. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal.

Authors: L E Benjamin; D Golijanin; A Itin; D Pode; E Keshet
Journal: J Clin Invest Date: 1999-01 Impact factor: 14.808

10. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis.

Authors: M Hellström; H Gerhardt; M Kalén; X Li; U Eriksson; H Wolburg; C Betsholtz
Journal: J Cell Biol Date: 2001-04-30 Impact factor: 10.539

59 in total

Review 1. Targeting angiogenesis in advanced cervical cancer.

Authors: Ramez N Eskander; Krishnansu S Tewari
Journal: Ther Adv Med Oncol Date: 2014-11 Impact factor: 8.168

Review 2. Adding to the mix: fibroblast growth factor and platelet-derived growth factor receptor pathways as targets in non-small cell lung cancer.

Authors: S A Kono; L E Heasley; R C Doebele; D R Camidge
Journal: Curr Cancer Drug Targets Date: 2012-02 Impact factor: 3.428

3. Role of bone marrow-derived cells in angiogenesis: focus on macrophages and pericytes.

Authors: Yanping Ding; Nan Song; Yongzhang Luo
Journal: Cancer Microenviron Date: 2012-04-20

Review 4. Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.

Authors: Shom Goel; Andus Hon-Kit Wong; Rakesh K Jain
Journal: Cold Spring Harb Perspect Med Date: 2012-03 Impact factor: 6.915

5. Beyond antiangiogenesis: vascular modulation as an anticancer therapy-a review.

Authors: Bryan T Oronsky; Jan J Scicinski; Tony Reid; Susan Knox
Journal: Transl Oncol Date: 2012-06-01 Impact factor: 4.243

6. "Mesenchymal" stem cells in human bone marrow (skeletal stem cells): a critical discussion of their nature, identity, and significance in incurable skeletal disease.

Authors: Paolo Bianco; Pamela Gehron Robey; Isabella Saggio; Mara Riminucci
Journal: Hum Gene Ther Date: 2010-09 Impact factor: 5.695

Review 7. Resistance to antiangiogenic therapy.

Authors: Shiao-Pei Weathers; John de Groot
Journal: Curr Neurol Neurosci Rep Date: 2014-05 Impact factor: 5.081

8. Blasts from the past.

Authors: Paul A Insel; Stuart Kornfeld; Philip W Majerus; Andrew R Marks; Paul A Marks; Arnold S Relman; Bruce F Scharschmidt; Thomas P Stossel; Ajit P Varki; Stephen J Weiss; Jean D Wilson
Journal: J Clin Invest Date: 2004-10 Impact factor: 14.808

9. Integrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation.

Authors: Barbara Garmy-Susini; Hui Jin; Yuhong Zhu; Rou-Jia Sung; Rosa Hwang; Judy Varner
Journal: J Clin Invest Date: 2005-05-02 Impact factor: 14.808

10. Pericytes Elicit Resistance to Vemurafenib and Sorafenib Therapy in Thyroid Carcinoma via the TSP-1/TGFβ1 Axis.

Authors: Alessandro Prete; Agnes S Lo; Peter M Sadow; Swati S Bhasin; Zeus A Antonello; Danica M Vodopivec; Soumya Ullas; Jennifer N Sims; John Clohessy; Ann M Dvorak; Tracey Sciuto; Manoj Bhasin; Joanne E Murphy-Ullrich; Jack Lawler; S Ananth Karumanchi; Carmelo Nucera
Journal: Clin Cancer Res Date: 2018-08-03 Impact factor: 12.531