Literature DB >> 14561165

Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.

Takanori Kanai1, Koji Uraushihara, Teruji Totsuka, Akira Okazawa, Toshifumi Hibi, Shigeru Oshima, Tatsuya Miyata, Tetsuya Nakamura, Mamoru Watanabe.   

Abstract

Crohn's disease is an inflammatory bowel disease associated with several changes in the immune system, including an increased number of infiltrating macrophages. These macrophages release a variety of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha, macrophage infiltrating factor (MIF), interleukin (IL)-6, IL-12 and IL-18, which are critically involved in the onset and the development of Crohn's disease. We here focus on the role of macrophages, especially macrophage-derived IL-18 in both patients with Crohn's disease and a murine model of Crohn's disease.

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Year:  2003        PMID： 14561165     DOI： 10.2174/1568010033484250

Source DB:  PubMed          Journal:  Curr Drug Targets Inflamm Allergy        ISSN： 1568-010X


  9 in total

1.  Treatment with interleukin-18 binding protein ameliorates Toxoplasma gondii-induced small intestinal pathology that is induced by bone marrow cell-derived interleukin-18.

Authors:  D Struck; I Frank; S Enders; U Steinhoff; C Schmidt; A Stallmach; O Liesenfeld; M M Heimesaat
Journal:  Eur J Microbiol Immunol (Bp)       Date:  2012-09-10

2.  Stimulatory and costimulatory effects of IL-18 directed to different small intestinal CD43 T cell subsets.

Authors:  Dina Montufar-Solis; Heuy-Ching Wang; John R Klein
Journal:  J Leukoc Biol       Date:  2007-08-16       Impact factor: 4.962

3.  Intestinal overexpression of IL-18 promotes eosinophils-mediated allergic disorders.

Authors:  Alok K Verma; Hemanth Kumar Kandikattu; Murli Manohar; Anshi Shukla; Sathisha Upparahalli Venkateshaiah; Xiang Zhu; Anil Mishra
Journal:  Immunology       Date:  2019-03-21       Impact factor: 7.397

4.  Plasmodium yoelii macrophage migration inhibitory factor is necessary for efficient liver-stage development.

Authors:  Jessica L Miller; Anke Harupa; Stefan H I Kappe; Sebastian A Mikolajczak
Journal:  Infect Immun       Date:  2012-01-17       Impact factor: 3.441

5.  Recombinant human beta 2-defensin fusion proteins as a tool to investigate defensin structure and function in small human intestinal tissue samples.

Authors:  Annekatrin Coordes; Andreas Andreou; Ulrike Erben; Thorsten Stroh; Katja Blunert; Nadia Slavova; Britta Siegmund; Heinz-Johannes Buhr; Anton J Kroesen
Journal:  Inflamm Res       Date:  2012-08-26       Impact factor: 4.575

6.  Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury.

Authors:  Zhibin He; Lawrence Lu; Christopher Altmann; Thomas S Hoke; Danica Ljubanovic; Alkesh Jani; Charles A Dinarello; Sarah Faubel; Charles L Edelstein
Journal:  Am J Physiol Renal Physiol       Date:  2008-08-27

Review 7.  Tumor-Associated Macrophages: Key Players in Triple-Negative Breast Cancer.

Authors:  Xia Qiu; Tianjiao Zhao; Ran Luo; Ran Qiu; Zhaoming Li
Journal:  Front Oncol       Date:  2022-02-14       Impact factor: 6.244

8.  Runx3 Mediates Resistance to Intracellular Bacterial Infection by Promoting IL12 Signaling in Group 1 ILC and NCR+ILC3.

Authors:  Shengxia Yin; Jingjing Yu; Bian Hu; Chenyu Lu; Xia Liu; Xianzhi Gao; Wei Li; Lina Zhou; Jianli Wang; Di Wang; Linrong Lu; Lie Wang
Journal:  Front Immunol       Date:  2018-09-12       Impact factor: 7.561

Review 9.  Saporin as a Commercial Reagent: Its Uses and Unexpected Impacts in the Biological Sciences-Tools from the Plant Kingdom.

Authors:  Leonardo R Ancheta; Patrick A Shramm; Raschel Bouajram; Denise Higgins; Douglas A Lappi
Journal:  Toxins (Basel)       Date:  2022-03-02       Impact factor: 4.546
  9 in total

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