| Literature DB >> 14560158 |
Mathilde Jalving1, Jan J Koornstra, Jan M Götz, Laurens A van der Waaij, Steven de Jong, Nynke Zwart, Arend Karrenbeld, Jan H Kleibeuker.
Abstract
We present a case of fundic gland polyps (FGPs) containing high-grade dysplasia in a 68-year-old man. High-grade dysplasia, and even gastric adenocarcinoma, associated with FGPs have been described in patients with familial adenomatous polyposis (FAP) and attenuated familial adenomatous polyposis (AFAP) but never in non-FAP patients. Two colonoscopies in the past six years virtually rule out FAP and AFAP in our patient. Dysplasia in FGPs from non-FAP patients is extremely rare, and until now only cases of low-grade dysplasia have been described. The literature on dysplasia in FGPs is reviewed briefly. Additional immunohistochemical investigations in this case showed nuclear staining of beta-catenin, increased proliferation and apoptosis in the dysplastic areas of the FGPs. Our case suggests that the malignant potential of FGPs is not limited to FAP-associated FGPs.Entities:
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Year: 2003 PMID： 14560158 DOI： 10.1097/00042737-200311000-00013
Source DB: PubMed Journal: Eur J Gastroenterol Hepatol ISSN： 0954-691X Impact factor: 2.566