Literature DB >> 14559369

Cortical changes in cholecystokinin mRNA are related to spontaneous pain behaviors following excitotoxic spinal cord injury in the rat.

Kori L Brewer1, David McMillan, Todd Nolan, Kerry Shum.   

Abstract

Cholecystokinin (CCK) in the CNS antagonizes the opioid system and has been implicated post-spinal cord injury (SCI) pain. The current study found that excitotoxic SCI alters levels of CCK mRNA levels in the cortex, diencepahlon, and mesencephalon of rats. Animals that developed pain post-SCI had significantly higher levels than animals that did not develop pain. Upregulation of CCK mRNA in the cortex may be related to post-SCI pain in rats.

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Year:  2003        PMID： 14559369     DOI： 10.1016/j.molbrainres.2003.08.006

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  3 in total

1.  Effect of the Combination of CI-988 and Morphine on Neuropathic Pain after Spinal Cord Injury in Rats.

Authors:  Junesun Kim; Youngkyung Kim; Suk-Chan Hahm; Young Wook Yoon
Journal:  Korean J Physiol Pharmacol       Date:  2015-02-25       Impact factor: 2.016

2.  Predifferentiated embryonic stem cells prevent chronic pain behaviors and restore sensory function following spinal cord injury in mice.

Authors:  Wesley A Hendricks; Elena S Pak; J Paul Owensby; Kristie J Menta; Margarita Glazova; Justin Moretto; Sarah Hollis; Kori L Brewer; Alexander K Murashov
Journal:  Mol Med       Date:  2006 Jan-Mar       Impact factor: 6.354

3.  Spinal and supraspinal changes in tumor necrosis factor-alpha expression following excitotoxic spinal cord injury.

Authors:  Kori L Brewer; Todd A Nolan
Journal:  J Mol Neurosci       Date:  2007       Impact factor: 3.444
  3 in total

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