| Literature DB >> 14559160 |
Javier Sáez-Valero1, Carmen González-García, Valentín Ceña.
Abstract
Biochemical changes in rat brain acetylcholinesterase (AChE) activity and molecular isoform distribution were studied using the middle cerebral artery occlusion model. After 24 h of permanent focal ischemia, AChE specific activity from infarcted cortex was found to decrease compared with contralateral cortex. Also a decrease in the minor monomeric (G1) form of AChE is response to ischemia was observed. Ischemia-induced AChE decrease was partially diminished by pre-treatment with dizocilpine (MK-801), a neuroprotective NMDA receptor blocker.Entities:
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Year: 2003 PMID： 14559160 DOI： 10.1016/s0169-328x(03)00324-3
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X