M J Firbank1, T Minett, J T O'Brien. 1. Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK. m.j.firbank@ncl.ac.uk
Abstract
OBJECTIVE: To assess normal-appearing white matter (NAWM) characteristics by magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI) in elderly subjects. METHODS: The authors studied 60 volunteers (mean age 72.6 years; SD 4.7; range 64 to 84 years) without signs of neurologic illness. They used DWI and spectroscopic imaging to investigate whether there were changes in the NAWM that related to the presence of white matter hyperintensities (WMH). RESULTS: The authors found a correlation (p < 0.001) between the apparent diffusion coefficient in the NAWM and the total volume of WMH. The metabolite ratios N-acetylaspartate/creatine and N-acetylaspartate/choline of the NAWM also correlated significantly with total WMH volume. These correlations were independent of age. CONCLUSIONS: Damage associated with WMH is detectable in NAWM.
OBJECTIVE: To assess normal-appearing white matter (NAWM) characteristics by magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI) in elderly subjects. METHODS: The authors studied 60 volunteers (mean age 72.6 years; SD 4.7; range 64 to 84 years) without signs of neurologic illness. They used DWI and spectroscopic imaging to investigate whether there were changes in the NAWM that related to the presence of white matter hyperintensities (WMH). RESULTS: The authors found a correlation (p < 0.001) between the apparent diffusion coefficient in the NAWM and the total volume of WMH. The metabolite ratios N-acetylaspartate/creatine and N-acetylaspartate/choline of the NAWM also correlated significantly with total WMH volume. These correlations were independent of age. CONCLUSIONS: Damage associated with WMH is detectable in NAWM.
Authors: T M Polvikoski; E C W van Straaten; F Barkhof; R Sulkava; H J Aronen; L Niinistö; M Oinas; P Scheltens; T Erkinjuntti; R N Kalaria Journal: Neurology Date: 2010-11-03 Impact factor: 9.910
Authors: Aart Spilt; Tychon Geeraedts; Anton J M de Craen; Rudi G J Westendorp; Gerard J Blauw; Mark A van Buchem Journal: AJNR Am J Neuroradiol Date: 2005-04 Impact factor: 3.825
Authors: Kejal Kantarci; Stephen D Weigand; Ronald C Petersen; Bradley F Boeve; David S Knopman; Jeffrey Gunter; Denise Reyes; Maria Shiung; Peter C O'Brien; Glenn E Smith; Robert J Ivnik; Eric G Tangalos; Clifford R Jack Journal: Neurobiol Aging Date: 2006-07-24 Impact factor: 4.673
Authors: Michael J Firbank; Rebecca M Wiseman; Emma J Burton; Brian K Saxby; John T O'Brien; Gary A Ford Journal: J Neurol Date: 2007-04-20 Impact factor: 4.849
Authors: Thais Minett; Li Su; Elijah Mak; Guy Williams; Michael Firbank; Rachael A Lawson; Alison J Yarnall; Gordon W Duncan; Adrian M Owen; Tien K Khoo; David J Brooks; James B Rowe; Roger A Barker; David Burn; John T O'Brien Journal: J Neurol Date: 2018-04-25 Impact factor: 4.849
Authors: Marcus V Zanetti; Maristela S Schaufelberger; Cláudio C de Castro; Paulo R Menezes; Márcia Scazufca; Philip K McGuire; Robin M Murray; Geraldo F Busatto Journal: Br J Psychiatry Date: 2008-07 Impact factor: 9.319
Authors: Masafumi Ihara; Tuomo M Polvikoski; Ros Hall; Janet Y Slade; Robert H Perry; Arthur E Oakley; Elisabet Englund; John T O'Brien; Paul G Ince; Raj N Kalaria Journal: Acta Neuropathol Date: 2010-01-21 Impact factor: 17.088