| Literature DB >> 14557050 |
Jane Worthington1, Sally John.
Abstract
The identification of functionally relevant polymorphisms of peptidylarginine deiminase 4, an enzyme that catalyzes the post-translational citrullination of proteins, as a rheumatoid arthritis gene is one of the most convincing success stories of complex disease gene mapping to date. In addition to an extensive single nucleotide polymorphism-based association study in a Japanese cohort, a range of techniques have been used to validate this finding.Entities:
Mesh：
Substances：
Year: 2003 PMID： 14557050 DOI： 10.1016/j.molmed.2003.08.007
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951