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Literature DB >> 14556053

Unraveling the multiple roles of leptin in inflammation and autoimmunity.

Antonio La Cava¹, Carlo Alviggi, Giuseppe Matarese.

Abstract

Initially described as an antiobesity hormone, leptin has subsequently been shown also to influence hematopoiesis, thermogenesis, reproduction, angiogenesis, and immune homeostasis. Leptin links nutritional status and proinflammatory T helper 1 immune responses, and the decrease in leptin plasma concentration during food deprivation leads to impaired immune function. This review focuses on the multiple roles of leptin in chronic inflammation and autoimmunity and suggests new possible therapeutic implications for leptin modulators.

Entities: Disease Gene

Mesh：

Substances：
Leptin

Year: 2003 PMID： 14556053 DOI： 10.1007/s00109-003-0492-1

Source DB: PubMed Journal: J Mol Med (Berl) ISSN： 0946-2716 Impact factor: 4.599

46 in total

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Review 10. Immunometabolism and autoimmunity.

Authors: Jenny Freitag; Luciana Berod; Thomas Kamradt; Tim Sparwasser
Journal: Immunol Cell Biol Date: 2016-08-26 Impact factor: 5.126