STUDY OBJECTIVE: We conducted the first randomized controlled study to assess the effects of short-term 28% and 100% oxygen on PaCO(2) and peak expiratory flow rate (PEFR) in patients with acute severe asthma. PATIENTS AND INTERVENTIONS:Seventy-four patients (mean age, 37.9 +/- 9.7 years [+/- SD]; PEFR, 41.0 +/- 12.1% of predicted) from two emergency departments were randomized to receive 28% or 100% oxygen during 20 min. RESULTS: The administration of 100% oxygen significantly increases PaCO(2) (p = 0.03) and decreases PEFR (p = 0.001) as compared with administration of 28% oxygen. PaCO(2) before and during oxygen administration correlated significantly (p = 0.001) in both groups. Patients breathing 28% oxygen experienced a PaCO(2) fall; on the contrary, patients who received 100% oxygen showed an increase in PaCO(2), particularly those with PaCO(2) before oxygen treatment > 40 mm Hg. CONCLUSIONS: This study confirmed previous observations that oxygen dose should be variable and based on achieving and maintaining target arterial oxygen saturation measured by pulse oximetry > or = 92% rather than on prescribing predetermined concentrations or flow rates of inspired oxygen.
RCT Entities:
STUDY OBJECTIVE: We conducted the first randomized controlled study to assess the effects of short-term 28% and 100% oxygen on PaCO(2) and peak expiratory flow rate (PEFR) in patients with acute severe asthma. PATIENTS AND INTERVENTIONS: Seventy-four patients (mean age, 37.9 +/- 9.7 years [+/- SD]; PEFR, 41.0 +/- 12.1% of predicted) from two emergency departments were randomized to receive 28% or 100% oxygen during 20 min. RESULTS: The administration of 100% oxygen significantly increases PaCO(2) (p = 0.03) and decreases PEFR (p = 0.001) as compared with administration of 28% oxygen. PaCO(2) before and during oxygen administration correlated significantly (p = 0.001) in both groups. Patients breathing 28% oxygen experienced a PaCO(2) fall; on the contrary, patients who received 100% oxygen showed an increase in PaCO(2), particularly those with PaCO(2) before oxygen treatment > 40 mm Hg. CONCLUSIONS: This study confirmed previous observations that oxygen dose should be variable and based on achieving and maintaining target arterial oxygen saturation measured by pulse oximetry > or = 92% rather than on prescribing predetermined concentrations or flow rates of inspired oxygen.
Authors: Rick Hodder; M Diane Lougheed; Brian H Rowe; J Mark FitzGerald; Alan G Kaplan; R Andrew McIvor Journal: CMAJ Date: 2009-10-26 Impact factor: 8.262
Authors: Mohamed S Al-Moamary; Sami A Alhaider; Abdullah A Alangari; Mohammed O Al Ghobain; Mohammed O Zeitouni; Majdy M Idrees; Abdullah F Alanazi; Adel S Al-Harbi; Abdullah A Yousef; Hassan S Alorainy; Mohamed S Al-Hajjaj Journal: Ann Thorac Med Date: 2019 Jan-Mar Impact factor: 2.219
Authors: Marija Barbateskovic; Olav L Schjørring; Sara Russo Krauss; Janus C Jakobsen; Christian S Meyhoff; Rikke M Dahl; Bodil S Rasmussen; Anders Perner; Jørn Wetterslev Journal: Cochrane Database Syst Rev Date: 2019-11-27
Authors: Helen K Reddel; Eric D Bateman; Allan Becker; Louis-Philippe Boulet; Alvaro A Cruz; Jeffrey M Drazen; Tari Haahtela; Suzanne S Hurd; Hiromasa Inoue; Johan C de Jongste; Robert F Lemanske; Mark L Levy; Paul M O'Byrne; Pierluigi Paggiaro; Soren E Pedersen; Emilio Pizzichini; Manuel Soto-Quiroz; Stanley J Szefler; Gary W K Wong; J Mark FitzGerald Journal: Eur Respir J Date: 2015-07-23 Impact factor: 16.671