Literature DB >> 14555496

Biosynthesis of glycosylphosphatidylinositol is essential to the survival of the protozoan parasite Toxoplasma gondii.

Michael J Wichroski1, Gary E Ward.   

Abstract

The PIGA gene from Toxoplasma gondii has been cloned and characterized. Like mammalian PIGA, the transmembrane and C-terminal domains are sufficient to direct localization to the parasite endoplasmic reticulum. A functional copy of PIGA is required for tachyzoite viability, demonstrating that glycosylphosphatidylinositol biosynthesis is an essential process in T. gondii.

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Year:  2003        PMID： 14555496      PMCID： PMC219362          DOI： 10.1128/EC.2.5.1132-1136.2003

Source DB:  PubMed          Journal:  Eukaryot Cell        ISSN： 1535-9786


  34 in total

1.  Glycosylphosphatidylinositols are required for the development of Trypanosoma cruzi amastigotes.

Authors:  N Garg; M Postan; K Mensa-Wilmot; R L Tarleton
Journal:  Infect Immun       Date:  1997-10       Impact factor: 3.441

Review 2.  GPI-anchor synthesis in mammalian cells: genes, their products, and a deficiency.

Authors:  T Kinoshita; K Ohishi; J Takeda
Journal:  J Biochem       Date:  1997-08       Impact factor: 3.387

3.  Gene knock-outs and allelic replacements in Toxoplasma gondii: HXGPRT as a selectable marker for hit-and-run mutagenesis.

Authors:  R G Donald; D S Roos
Journal:  Mol Biochem Parasitol       Date:  1998-03-15       Impact factor: 1.759

4.  The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1.

Authors:  R Watanabe; N Inoue; B Westfall; C H Taron; P Orlean; J Takeda; T Kinoshita
Journal:  EMBO J       Date:  1998-02-16       Impact factor: 11.598

5.  Targeting the secretory pathway of Toxoplasma gondii.

Authors:  V Karsten; H Qi; C J Beckers; K A Joiner
Journal:  Methods       Date:  1997-10       Impact factor: 3.608

6.  Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana.

Authors:  S C Ilgoutz; J L Zawadzki; J E Ralton; M J McConville
Journal:  EMBO J       Date:  1999-05-17       Impact factor: 11.598

7.  The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase.

Authors:  J Yu; S Nagarajan; J J Knez; S Udenfriend; R Chen; M E Medof
Journal:  Proc Natl Acad Sci U S A       Date:  1997-11-11       Impact factor: 11.205

8.  Yeast Gpi8p is essential for GPI anchor attachment onto proteins.

Authors:  M Benghezal; A Benachour; S Rusconi; M Aebi; A Conzelmann
Journal:  EMBO J       Date:  1996-12-02       Impact factor: 11.598

9.  Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors.

Authors:  V M Gordon; K L Nelson; J T Buckley; V L Stevens; R K Tweten; P C Elwood; S H Leppla
Journal:  J Biol Chem       Date:  1999-09-17       Impact factor: 5.157

Review 10.  The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research.

Authors:  M A Ferguson
Journal:  J Cell Sci       Date:  1999-09       Impact factor: 5.285
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  10 in total

Review 1.  Functional aspects of Toll-like receptor/MyD88 signalling during protozoan infection: focus on Toxoplasma gondii.

Authors:  C E Egan; W Sukhumavasi; B A Butcher; E Y Denkers
Journal:  Clin Exp Immunol       Date:  2009-01-21       Impact factor: 4.330

2.  Two phylogenetically and compartmentally distinct CDP-diacylglycerol synthases cooperate for lipid biogenesis in Toxoplasma gondii.

Authors:  Pengfei Kong; Christoph-Martin Ufermann; Diana L M Zimmermann; Qing Yin; Xun Suo; J Bernd Helms; Jos F Brouwers; Nishith Gupta
Journal:  J Biol Chem       Date:  2017-03-17       Impact factor: 5.157

Review 3.  Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans.

Authors:  Srinivasan Ramakrishnan; Mauro Serricchio; Boris Striepen; Peter Bütikofer
Journal:  Prog Lipid Res       Date:  2013-07-01       Impact factor: 16.195

Review 4.  Dysregulation of macrophage signal transduction by Toxoplasma gondii: past progress and recent advances.

Authors:  J Leng; B A Butcher; E Y Denkers
Journal:  Parasite Immunol       Date:  2009-12       Impact factor: 2.280

5.  Toxoplasma gondii prevents chromatin remodeling initiated by TLR-triggered macrophage activation.

Authors:  Jin Leng; Barbara A Butcher; Charlotte E Egan; Delbert S Abi Abdallah; Eric Y Denkers
Journal:  J Immunol       Date:  2009-01-01       Impact factor: 5.422

6.  Blocking Palmitoylation of Toxoplasma gondii Myosin Light Chain 1 Disrupts Glideosome Composition but Has Little Impact on Parasite Motility.

Authors:  Pramod K Rompikuntal; Robyn S Kent; Ian T Foe; Bin Deng; Matthew Bogyo; Gary E Ward
Journal:  mSphere       Date:  2021-05-19       Impact factor: 4.389

7.  Virulent and avirulent strains of Toxoplasma gondii which differ in their glycosylphosphatidylinositol content induce similar biological functions in macrophages.

Authors:  Sebastian Niehus; Terry K Smith; Nahid Azzouz; Marco A Campos; Jean-François Dubremetz; Ricardo T Gazzinelli; Ralph T Schwarz; Françoise Debierre-Grockiego
Journal:  PLoS One       Date:  2014-01-28       Impact factor: 3.240

8.  Isolation and purification of glycosylphosphatidylinositols (GPIs) in the schizont stage of Theileria annulata and determination of antibody response to GPI anchors in vaccinated and infected animals.

Authors:  Toktam Abbasnia; Ahmad Asoodeh; Gholamreza Habibi; Alireza Haghparast
Journal:  Parasit Vectors       Date:  2018-02-06       Impact factor: 3.876

9.  Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii.

Authors:  Bingjian Ren; Pengfei Kong; Fatima Hedar; Jos F Brouwers; Nishith Gupta
Journal:  Commun Biol       Date:  2020-12-10

Review 10.  Glycobiology of Human Fungal Pathogens: New Avenues for Drug Development.

Authors:  Danielle J Lee; Holly O'Donnell; Françoise H Routier; Joe Tiralongo; Thomas Haselhorst
Journal:  Cells       Date:  2019-10-30       Impact factor: 6.600
  10 in total

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