Respiratory toxicology of mineral oils in laboratory animals.

Early subchronic and chronic inhalation toxicology studies on various petroleum mineral oils and formulated lubricants supported the ACGIH TLV of 5 mg/m(3) for mineral oil mist. Additional subchronic studies with aerosolized mineral base oils and lubricants during the last 15 years demonstrated that exposures to aerosols of mineral base oils (often >100 mg/m(3)) resulted mainly in concentration-related accumulation in the lung of alveolar macrophages laden with oil droplets. Inflammatory cells were observed with higher aerosol concentrations, consistent with the clinical literature from highly exposed workers. These pulmonary changes appeared to be a nonspecific response to the presence of deposited aerosol. Studies on sensory irritation during exposures of lab animals to mineral oils indicate possible effects only with very high aerosol concentrations. Coupled with changes in refining to remove carcinogenic polynuclear aromatic hydrocarbons from mineral oils several decades ago, this information indicates that current aerosols of mineral oils have a profile of low toxicity from acute to long-term exposures. Available information suggests that additives in some formulated products and/or maintenance of mineral-based metalworking fluids may play a much more significant role in potential health effects.