| Literature DB >> 1455450 |
S E Theocharis1, A P Margeli, I K Ghiconti, D Varonos.
Abstract
Intraperitoneal (i.p.) administration of a cadmium (Cd) salt at concentrations of 1.0, 2.5 and 4.0 mg CdCl2/kg body wt. caused severe liver injury in rats 24 h after administration. The toxic effects were most evident in the intermediate dose of 2.5 mg. Thymidine kinase (TK), the key enzyme of the salvage pathway of DNA biosynthesis, was affected in all Cd-treated groups. TK activity presented lower values at the highest Cd-induced hepatotoxicity.Entities:
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Year: 1992 PMID： 1455450 DOI： 10.1016/0378-4274(92)90010-h
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372