| Literature DB >> 14554254 |
Jose Lopez1, John Copps, Catherine Wilhelmsen, Richard Moore, Julie Kubay, Marcel St-Jacques, Stacey Halayko, Christiaan Kranendonk, Shannon Toback, David DeShazer, David L Fritz, Marina Tom, Donald E Woods.
Abstract
Considerable advances in understanding of the disease caused by Burkholderia mallei have been made employing a combination of tools including genetic techniques and animal infection models. The development of small animal models has allowed us to assess the role of a number of putative virulence determinants in the pathogenesis of disease due to B. mallei. Due to the difficulties in performing active immunization studies in small animals, and due to the fact that the horse is the target mammalian species for glanders, we have initiated experimental studies on glanders in horses. Intratracheal deposition of B. mallei produced clinical glanders with organisms being recovered from tissues of infected horses. The model should prove to be of considerable value in our ongoing studies on the pathogenesis and vaccine development for glanders.Entities:
Mesh：
Year: 2003 PMID： 14554254 DOI： 10.1016/j.micinf.2003.07.004
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700