| Literature DB >> 14552835 |
Beatriz M Carreno1, Mary Collins.
Abstract
The B and T lymphocyte attenuator, BTLA, is a recently discovered Ig superfamily member. BTLA engagement results in downregulation of T-cell activation, and mice deficient in BTLA show increased incidence and severity of autoimmune disorders. A novel B7 family member, B7x (B7S1, B7-H4), has been proposed as the ligand for BTLA. A B7x-Ig fusion protein inhibits T-cell activation and interleukin-2 (IL-2) production. Thus, cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1) and BTLA comprise an expanding set of inhibitory receptors expressed on lymphocytes.Entities:
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Year: 2003 PMID： 14552835 DOI： 10.1016/j.it.2003.08.005
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687