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Literature DB >> 14552834

Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1.

Abstract

Self-renewal of hematopoietic stem cells is vital for the sustained daily production of blood cells. Two recent studies have shown that the Polycomb-group gene Bmi-1 is indispensable for regulation of self-renewal by normal and leukemic stem cells. This identifies Polycomb-group genes as potential targets for therapeutic intervention in leukemia, and possibly other forms of cancer.

Entities: Disease Gene

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Year: 2003 PMID： 14552834 DOI： 10.1016/s1471-4906(03)00241-2

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687

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Cited

37 in total

1. Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells.

Authors: Chance John Luckey; Deepta Bhattacharya; Ananda W Goldrath; Irving L Weissman; Christophe Benoist; Diane Mathis
Journal: Proc Natl Acad Sci U S A Date: 2006-02-21 Impact factor: 11.205

2. Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality.

Authors: Yuehai Ke; Eric E Zhang; Kazuki Hagihara; Dongmei Wu; Yuhong Pang; Rüdiger Klein; Tom Curran; Barbara Ranscht; Gen-Sheng Feng
Journal: Mol Cell Biol Date: 2007-07-23 Impact factor: 4.272

Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1.

1. Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells.

2. Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality.

Review 3. Targeting the leukemic stem cell: the Holy Grail of leukemia therapy.

4. MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies.

5. Subnuclear distribution of SSX regulates its function.

6. BMI-1, a promising therapeutic target for human cancer.

7. Characterization of mammary cancer stem cells in the MMTV-PyMT mouse model.

8. MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer.

9. BMI-1 expression is inversely correlated with the grading of renal clear cell carcinoma.

10. SALL4 is a key regulator of survival and apoptosis in human leukemic cells.