Literature DB >> 14552795

Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists.

István Borza1, Sándor Kolok, Anikó Gere, Eva Agai-Csongor, Béla Agai, Gábor Tárkányi, Csilla Horváth, Gizella Barta-Szalai, Eva Bozó, Csilla Kiss, Attila Bielik, József Nagy, Sándor Farkas, György Domány.   

Abstract

A novel series of indole-2-carboxamide derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the number and position of OH groups on the indole skeleton as well as the substitution of the piperidine ring on the biological activity of the compounds was studied.

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Year:  2003        PMID: 14552795     DOI: 10.1016/s0960-894x(03)00708-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  4 in total

1.  Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.

Authors:  Yesim A Tahirovic; Matthew Geballe; Ewa Gruszecka-Kowalik; Scott J Myers; Polina Lyuboslavsky; Phuong Le; Adam French; Hasan Irier; Woo-Baeg Choi; Keith Easterling; Hongjie Yuan; Lawrence J Wilson; Robert Kotloski; James O McNamara; Raymond Dingledine; Dennis C Liotta; Stephen F Traynelis; James P Snyder
Journal:  J Med Chem       Date:  2008-09-25       Impact factor: 7.446

2.  Role of altered structure and function of NMDA receptors in development of alcohol dependence.

Authors:  József Nagy; Sándor Kolok; András Boros; Péter Dezso
Journal:  Curr Neuropharmacol       Date:  2005-10       Impact factor: 7.363

3.  Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.

Authors:  Cara A Mosley; Scott J Myers; Ernest E Murray; Rose Santangelo; Yesim A Tahirovic; Natalie Kurtkaya; Praseeda Mullasseril; Hongjie Yuan; Polina Lyuboslavsky; Phuong Le; Lawrence J Wilson; Manuel Yepes; Ray Dingledine; Stephen F Traynelis; Dennis C Liotta
Journal:  Bioorg Med Chem       Date:  2009-07-05       Impact factor: 3.641

4.  Alcohol related changes in regulation of NMDA receptor functions.

Authors:  József Nagy
Journal:  Curr Neuropharmacol       Date:  2008-03       Impact factor: 7.363

  4 in total

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