| Literature DB >> 14552791 |
Concha Sanchez-Martinez1, Chuan Shih, Margaret M Faul, Guoxin Zhu, Michael Paal, Carmen Somoza, Tiechao Li, Christine A Kumrich, Leonard L Winneroski, Zhou Xun, Harold B Brooks, Bharvin K R Patel, Richard M Schultz, Tammy B DeHahn, Charles D Spencer, Scott A Watkins, Eileen Considine, Jack A Dempsey, Catherine A Ogg, Robert M Campbell, Bryan A Anderson, Jill Wagner.
Abstract
The synthesis of new analogues of Arcyriaflavin A in which one indole ring is replaced by an aryl or heteroaryl ring is described. These new series of aryl[a]pyrrolo[3,4-c]carbazoles were evaluated as inhibitors of Cyclin D1-CDK4. A potent and selective D1-CDK4 inhibitor, 7a (D1-CDK4 IC(50)=45 nM), has been identified. The potency, selectivity profile against other kinases, and structure-activity relationship (SAR) trends of this class of compounds are discussed.Entities:
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Year: 2003 PMID： 14552791 DOI： 10.1016/s0960-894x(03)00791-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823