Literature DB >> 14552790

Ganglioside GM1 mimics: lipophilic substituents improve affinity for cholera toxin.

Daniela Arosio1, Sergio Baretti, Stefania Cattaldo, Donatella Potenza, Anna Bernardi.   

Abstract

Ganglioside GM1 mimics including (R)-2-hydroxy-3-cyclohexylpropionic acid or (R)-2-hydroxy-3-phenylpropionic acid as replacements for NeuAc are stronger cholera toxin binders than the parent ligand 2, which includes (R)-2-hydroxy-propionic acid.

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Year:  2003        PMID： 14552790     DOI： 10.1016/j.bmcl.2003.07.007

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Cholera toxin inhibitors studied with high-performance liquid affinity chromatography: a robust method to evaluate receptor-ligand interactions.

Authors:  Maria Bergström; Shuang Liu; Kristi L Kiick; Sten Ohlson
Journal:  Chem Biol Drug Des       Date:  2009-01       Impact factor: 2.817

2.  Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B.

Authors:  Serena Monaco; Samuel Walpole; Hassan Doukani; Ridvan Nepravishta; Macarena Martínez-Bailén; Ana T Carmona; Javier Ramos-Soriano; Maria Bergström; Inmaculada Robina; Jesus Angulo
Journal:  Chemistry       Date:  2020-07-20       Impact factor: 5.236

3.  Screening of a Glycopolymer Library of GM1 Mimics Containing Hydrophobic Units Using Surface Plasmon Resonance Imaging.

Authors:  Yuri Kimoto; Yuhei Terada; Yu Hoshino; Yoshiko Miura
Journal:  ACS Omega       Date:  2019-11-26
  3 in total

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