Literature DB >> 14552789

Structure elucidation of Sch 538415, a novel acyl carrier protein synthase inhibitor from a microorganism.

Min Chu1, Ronald Mierzwa, Ling Xu, Shu-Wei Yang, Ling He, Mahesh Patel, Jill Stafford, David Macinga, Todd Black, Tze-Ming Chan, Vincent Gullo.   

Abstract

A novel acyl carrier protein synthase inhibitor, Sch 538415 (1), was isolated from an unidentified bacterial microbe. Structure elucidation of 1 was accomplished based on analysis of spectroscopic data including UV, MS and 2D-NMR spectra. Compound 1 exhibited inhibitory activity in the acyl carrier protein synthase (AcpS) assay with an IC(50) value of 4.19 microM and showed antibacterial activity against Staphylococcus aureus in the agar diffusion assay.

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Year:  2003        PMID： 14552789     DOI： 10.1016/j.bmcl.2003.07.011

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Preparation of FRET reporters to support chemical probe development.

Authors:  Timothy L Foley; Adam Yasgar; Christopher J Garcia; Ajit Jadhav; Anton Simeonov; Michael D Burkart
Journal:  Org Biomol Chem       Date:  2010-08-20       Impact factor: 3.876

Review 2.  The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life.

Authors:  Joris Beld; Eva C Sonnenschein; Christopher R Vickery; Joseph P Noel; Michael D Burkart
Journal:  Nat Prod Rep       Date:  2014-01       Impact factor: 13.423

3.  Diazaquinomycin Biosynthetic Gene Clusters from Marine and Freshwater Actinomycetes.

Authors:  Jana Braesel; Jung-Ho Lee; Benoit Arnould; Brian T Murphy; Alessandra S Eustáquio
Journal:  J Nat Prod       Date:  2019-03-21       Impact factor: 4.050

Review 4.  Mining Fatty Acid Biosynthesis for New Antimicrobials.

Authors:  Christopher D Radka; Charles O Rock
Journal:  Annu Rev Microbiol       Date:  2022-06-01       Impact factor: 16.232

5.  A homogeneous resonance energy transfer assay for phosphopantetheinyl transferase.

Authors:  Timothy L Foley; Michael D Burkart
Journal:  Anal Biochem       Date:  2009-06-30       Impact factor: 3.365

6.  A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase.

Authors:  Adam Yasgar; Timothy L Foley; Ajit Jadhav; James Inglese; Michael D Burkart; Anton Simeonov
Journal:  Mol Biosyst       Date:  2009-10-13

7.  Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated Streptomyces.

Authors:  Xiachang Wang; Sherif I Elshahawi; Larissa V Ponomareva; Qing Ye; Yang Liu; Gregory C Copley; James C Hower; Bruce E Hatcher; Madan K Kharel; Steven G Van Lanen; Qing-Bai She; S Randal Voss; Jon S Thorson; Khaled A Shaaban
Journal:  J Nat Prod       Date:  2019-12-13       Impact factor: 4.050

8.  Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria.

Authors:  Andrei S Halavaty; Youngchang Kim; George Minasov; Ludmilla Shuvalova; Ievgeniia Dubrovska; James Winsor; Min Zhou; Olena Onopriyenko; Tatiana Skarina; Leka Papazisi; Keehwan Kwon; Scott N Peterson; Andrzej Joachimiak; Alexei Savchenko; Wayne F Anderson
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2012-09-13

9.  Pseudonocardians A-C, new diazaanthraquinone derivatives from a deap-sea actinomycete Pseudonocardia sp. SCSIO 01299.

Authors:  Sumei Li; Xinpeng Tian; Siwen Niu; Wenjun Zhang; Yuchan Chen; Haibo Zhang; Xianwen Yang; Weimin Zhang; Wenjun Li; Si Zhang; Jianhua Ju; Changsheng Zhang
Journal:  Mar Drugs       Date:  2011-08-23       Impact factor: 6.085

10.  4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth.

Authors:  Timothy L Foley; Ganesha Rai; Adam Yasgar; Thomas Daniel; Heather L Baker; Matias Attene-Ramos; Nicolas M Kosa; William Leister; Michael D Burkart; Ajit Jadhav; Anton Simeonov; David J Maloney
Journal:  J Med Chem       Date:  2014-01-22       Impact factor: 7.446
  10 in total

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