| Literature DB >> 14552774 |
Nicholas J Lawrence1, David Rennison, Alan T McGown, John A Hadfield.
Abstract
The naturally occurring aurone 1, isolated from Uvaria hamiltonii, and a series of aurones analogues based structurally on known tubulin binding agents were prepared and evaluated for anticancer activity. Aurone 20 was the most active (IC(50) K562 50 nM) and caused significant G2/M cell-cycle arrest.Entities:
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Year: 2003 PMID： 14552774 DOI： 10.1016/j.bmcl.2003.07.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823