| Literature DB >> 14552761 |
Kenji Kinoshita1, Blaine A Pfeifer, Chaitan Khosla, David E Cane.
Abstract
Precursor-directed polyketide biosynthesis was demonstrated in the heterologous host Escherichia coli. Several diketide and triketide substrates were fed to a recombinant E. coli strain containing a variant form of deoxyerythronolide B synthase (DEBS) from which the first elongation module was deleted resulting in successful macrolactone formation from the diketide, but not the triketide, substrates.Entities:
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Year: 2003 PMID： 14552761 DOI： 10.1016/j.bmcl.2003.08.008
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823