Literature DB >> 14552589

Increased activity and expression of phospholipase D2 in human colorectal cancer.

Hirokazu Oshimoto1, Shinichi Okamura, Makoto Yoshida, Masatomo Mori.   

Abstract

Phospholipase D (PLD) has been reported as relevant to some types of human cancer, but its role in human colorectal cancer still remains to be elucidated. Thus, this study was conducted to determine the activity and the expression of PLD2 in human colorectal cancer. A significant elevation of PLD2 activity and higher expression of PLD2 protein were detected in human colorectal cancer in comparison with corresponding normal mucosa. The tendency of higher expression of PLD2 mRNA was also observed. The ratio of PLD2 activity in cancer to that in corresponding normal mucosa was greater in colorectal cancer with nodal involvement and deeper tumor invasion. Our results indicate that PLD2 has a possible implication in carcinogenesis and progression and would be a new therapeutic target and a potential tumor marker for colorectal cancer.

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Year:  2003        PMID： 14552589     DOI： 10.3727/000000003108748586

Source DB:  PubMed          Journal:  Oncol Res        ISSN： 0965-0407            Impact factor:   5.574


  16 in total

1.  Rebamipide-induced downregulation of phospholipase D inhibits inflammation and proliferation in gastric cancer cells.

Authors:  Dong Woo Kang; Gyesik Min; Do Yoon Park; Ki Whan Hong; Do Sik Min
Journal:  Exp Mol Med       Date:  2010-08-31       Impact factor: 8.718

2.  High Expression of PhospholipaseD2 Induced by Hypoxia Promotes Proliferation of Colon Cancer Cells through Activating NF- κ Bp65 Signaling Pathway.

Authors:  Maoxi Liu; Kunli Du; Bo Jiang; Xingye Wu
Journal:  Pathol Oncol Res       Date:  2018-08-08       Impact factor: 3.201

3.  Down-regulation of phospholipase D2 mRNA in neonatal rat brainstem and cerebellum after hypoxia-ischemia.

Authors:  Jeng-Hsiung F Peng; Yangzheng Feng; Philip G Rhodes
Journal:  Neurochem Res       Date:  2006-10-06       Impact factor: 3.996

4.  Requirement of phospholipase D1 activity in H-RasV12-induced transformation.

Authors:  F Gregory Buchanan; Matt McReynolds; Anthony Couvillon; Yoonseok Kam; Vijaykumar R Holla; Raymond N Dubois; John H Exton
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-24       Impact factor: 11.205

5.  Hypoxia-inducible factor 1-alpha up-regulates the expression of phospholipase D2 in colon cancer cells under hypoxic conditions.

Authors:  Maoxi Liu; Kunli Du; Zhongxue Fu; Shouru Zhang; Xingye Wu
Journal:  Med Oncol       Date:  2014-11-29       Impact factor: 3.064

Review 6.  Choline metabolism in malignant transformation.

Authors:  Kristine Glunde; Zaver M Bhujwalla; Sabrina M Ronen
Journal:  Nat Rev Cancer       Date:  2011-11-17       Impact factor: 60.716

7.  Two sites of action for PLD2 inhibitors: The enzyme catalytic center and an allosteric, phosphoinositide biding pocket.

Authors:  Ramya Ganesan; Madhu Mahankali; Gerald Alter; Julian Gomez-Cambronero
Journal:  Biochim Biophys Acta       Date:  2014-12-20

Review 8.  Biochemical and cellular implications of a dual lipase-GEF function of phospholipase D2 (PLD2).

Authors:  Julian Gomez-Cambronero
Journal:  J Leukoc Biol       Date:  2012-07-02       Impact factor: 4.962

9.  Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity.

Authors:  Madhu Mahankali; Karen M Henkels; Gerald Alter; Julian Gomez-Cambronero
Journal:  J Biol Chem       Date:  2012-10-03       Impact factor: 5.157

10.  Inhibition of phospholipaseD2 increases hypoxia-induced human colon cancer cell apoptosis through inactivating of the PI3K/AKT signaling pathway.

Authors:  Maoxi Liu; Zhongxue Fu; Xingye Wu; Kunli Du; Shouru Zhang; Li Zeng
Journal:  Tumour Biol       Date:  2015-11-27
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