Literature DB >> 14551895

Safety and immunogenicity of DNA/modified vaccinia virus ankara malaria vaccination in African adults.

Vasee S Moorthy1, Margaret Pinder, William H H Reece, Kate Watkins, Sowsan Atabani, Carolyn Hannan, Kalifa Bojang, Keith P W J McAdam, Joerg Schneider, Sarah Gilbert, Adrian V S Hill.   

Abstract

The present study is an investigation of the safety and immunogenicity of DNA and modified vaccinia virus Ankara (MVA) candidate vaccines, each encoding the malaria DNA sequence multiple epitope-thrombospondin related adhesion protein (ME-TRAP), against Plasmodium falciparum. DNA ME-TRAP and MVA ME-TRAP are safe and immunogenic for effector and memory T cell induction. MVA ME-TRAP, with or without prior DNA ME-TRAP immunization, was more immunogenic and more cross-reactive in malaria-exposed individuals than in malaria-naive individuals, a finding suggesting that recombinant MVA vaccines are particularly promising for the development of a malaria vaccine for exposed populations. Both CD4(+) and CD8(+) T cells were induced by these vaccines.

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Year:  2003        PMID： 14551895     DOI： 10.1086/378515

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  26 in total

1.  Safety, immunogenicity, and efficacy of prime-boost immunization with recombinant poxvirus FP9 and modified vaccinia virus Ankara encoding the full-length Plasmodium falciparum circumsporozoite protein.

Authors:  Michael Walther; Fiona M Thompson; Susanna Dunachie; Sheila Keating; Stephen Todryk; Tamara Berthoud; Laura Andrews; Rikke F Andersen; Anne Moore; Sarah C Gilbert; Ian Poulton; Filip Dubovsky; Eveline Tierney; Simon Correa; Angela Huntcooke; Geoffrey Butcher; Jack Williams; Robert E Sinden; Adrian V S Hill
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

2.  Induction of multifunctional human immunodeficiency virus type 1 (HIV-1)-specific T cells capable of proliferation in healthy subjects by using a prime-boost regimen of DNA- and modified vaccinia virus Ankara-vectored vaccines expressing HIV-1 Gag coupled to CD8+ T-cell epitopes.

Authors:  Nilu Goonetilleke; Stephen Moore; Len Dally; Nicola Winstone; Inese Cebere; Abdul Mahmoud; Susana Pinheiro; Geraldine Gillespie; Denise Brown; Vanessa Loach; Joanna Roberts; Ana Guimaraes-Walker; Peter Hayes; Kelley Loughran; Carole Smith; Jan De Bont; Carl Verlinde; Danii Vooijs; Claudia Schmidt; Mark Boaz; Jill Gilmour; Pat Fast; Lucy Dorrell; Tomas Hanke; Andrew J McMichael
Journal:  J Virol       Date:  2006-05       Impact factor: 5.103

3.  Modified vaccinia virus Ankara-based vaccine vectors induce apoptosis in dendritic cells draining from the skin via both the extrinsic and intrinsic caspase pathways, preventing efficient antigen presentation.

Authors:  E Guzman; C Cubillos-Zapata; M G Cottingham; S C Gilbert; H Prentice; B Charleston; J C Hope
Journal:  J Virol       Date:  2012-03-14       Impact factor: 5.103

4.  Gamma interferon responses to Plasmodium falciparum liver-stage antigen 1 and thrombospondin-related adhesive protein and their relationship to age, transmission intensity, and protection against malaria.

Authors:  Chandy C John; Ann M Moormann; Peter O Sumba; Ayub V Ofulla; Daniel C Pregibon; James W Kazura
Journal:  Infect Immun       Date:  2004-09       Impact factor: 3.441

5.  Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.

Authors:  D Lys Guilbride; Pawel Gawlinski; Patrick D L Guilbride
Journal:  PLoS One       Date:  2010-05-19       Impact factor: 3.240

6.  A heterologous DNA prime/protein boost immunization strategy for rhesus cytomegalovirus.

Authors:  Kristina Abel; Lisa Strelow; Yujuan Yue; Meghan K Eberhardt; Kimberli A Schmidt; Peter A Barry
Journal:  Vaccine       Date:  2008-08-27       Impact factor: 3.641

Review 7.  Egg-independent vaccine strategies for highly pathogenic H5N1 influenza viruses.

Authors:  Aseem Pandey; Neetu Singh; Suryaprakash Sambhara; Suresh K Mittal
Journal:  Hum Vaccin       Date:  2010-02-24

8.  Early gamma interferon and interleukin-2 responses to vaccination predict the late resting memory in malaria-naïve and malaria-exposed individuals.

Authors:  Philip Bejon; Sheila Keating; Jedidah Mwacharo; Oscar K Kai; Susanna Dunachie; Michael Walther; Tamara Berthoud; Trudie Lang; Judy Epstein; Daniel Carucci; Philippe Moris; Joe Cohen; Sarah C Gilbert; Norbert Peshu; Kevin Marsh; Adrian V S Hill
Journal:  Infect Immun       Date:  2006-09-11       Impact factor: 3.441

9.  A fusion protein of HCMV IE1 exon4 and IE2 exon5 stimulates potent cellular immunity in an MVA vaccine vector.

Authors:  Z Wang; W Zhou; T Srivastava; C La Rosa; A Mandarino; S J Forman; J A Zaia; W J Britt; D J Diamond
Journal:  Virology       Date:  2008-06-05       Impact factor: 3.616

10.  Translating the immunogenicity of prime-boost immunization with ChAd63 and MVA ME-TRAP from malaria naive to malaria-endemic populations.

Authors:  Domtila Kimani; Ya Jankey Jagne; Momodou Cox; Eva Kimani; Carly M Bliss; Evelyn Gitau; Caroline Ogwang; Muhammed O Afolabi; Georgina Bowyer; Katharine A Collins; Nick Edwards; Susanne H Hodgson; Christopher J A Duncan; Alexandra J Spencer; Miguel G Knight; Abdoulie Drammeh; Nicholas A Anagnostou; Eleanor Berrie; Sarah Moyle; Sarah C Gilbert; Peninah Soipei; Joseph Okebe; Stefano Colloca; Riccardo Cortese; Nicola K Viebig; Rachel Roberts; Alison M Lawrie; Alfredo Nicosia; Egeruan B Imoukhuede; Philip Bejon; Roma Chilengi; Kalifa Bojang; Katie L Flanagan; Adrian V S Hill; Britta C Urban; Katie J Ewer
Journal:  Mol Ther       Date:  2014-06-16       Impact factor: 11.454
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