AIMS: Comparison of the degradation of poly(D,L)lactide (Resorb X) or poly(lactide-co-glycolide) (LactoSorb) in vivo. MATERIAL AND METHODS: LactoSorb and Resorb X osteosynthesis plates were fixed at the lateral aspect of the femora of 26 Chinchilla rabbits using the respective osteosynthesis screws. After intraperitoneal injection of fluorochromes the screw plate bone blocks were resected after 1, 6, 12, 14, 16, 21, 26 months and radiologic, histologic as well as fluorescence microscopic examinations were carried out. RESULTS: Newly formed bone was detectable above and beneath the polymers 1 month after the implantation. The implants were totally covered by newly formed bone after 6 months. While the LactoSorb screws were found to be as birefringent as after 1 month, in the Resorb X screws a continuous resorption by phagocytizing marrow cells starting from the periphery was detectable. Resorb X was totally resorbed in histologic slides 12 months after implantation, while total resorption of LactoSorb lasted 14 months; both polymers were replaced by marrow cells. Bone remodeling was not finished 26 months after implantation in both polymers. CONCLUSION: Resorption of Resorb X was finished earlier than the resorption of LactoSorb. Both materials were found by fluorescence microscope to be completely resorbed after 12 or 14 months, but bone remodeling of the screw holes was not yet finished 26 months after implantation.
AIMS: Comparison of the degradation of poly(D,L)lactide (Resorb X) or poly(lactide-co-glycolide) (LactoSorb) in vivo. MATERIAL AND METHODS:LactoSorb and Resorb X osteosynthesis plates were fixed at the lateral aspect of the femora of 26 Chinchillarabbits using the respective osteosynthesis screws. After intraperitoneal injection of fluorochromes the screw plate bone blocks were resected after 1, 6, 12, 14, 16, 21, 26 months and radiologic, histologic as well as fluorescence microscopic examinations were carried out. RESULTS: Newly formed bone was detectable above and beneath the polymers 1 month after the implantation. The implants were totally covered by newly formed bone after 6 months. While the LactoSorb screws were found to be as birefringent as after 1 month, in the Resorb X screws a continuous resorption by phagocytizing marrow cells starting from the periphery was detectable. Resorb X was totally resorbed in histologic slides 12 months after implantation, while total resorption of LactoSorb lasted 14 months; both polymers were replaced by marrow cells. Bone remodeling was not finished 26 months after implantation in both polymers. CONCLUSION: Resorption of Resorb X was finished earlier than the resorption of LactoSorb. Both materials were found by fluorescence microscope to be completely resorbed after 12 or 14 months, but bone remodeling of the screw holes was not yet finished 26 months after implantation.
Authors: W Heidemann; S Jeschkeit; K Ruffieux; J H Fischer; M Wagner; G Krüger; E Wintermantel; K L Gerlach Journal: Biomaterials Date: 2001-09 Impact factor: 12.479
Authors: Wolfgang Heidemann; Stephanie Jeschkeit-Schubbert; Kurt Ruffieux; Jürgen Hartmut Fischer; Hedda Jung; Gerhard Krueger; Erich Wintermantel; Klaus Louis Gerlach Journal: Biomaterials Date: 2002-09 Impact factor: 12.479
Authors: Mehmet F Güleçyüz; Christian Schröder; Matthias F Pietschmann; Stephanie Göbel; Mario Lehmann; Jörg Mayer; Andreas Ficklscherer; Volkmar Jansson; Peter E Müller Journal: Acta Orthop Traumatol Turc Date: 2017-12-28 Impact factor: 1.511
Authors: Barzi Gareb; Nico B van Bakelen; Léon Driessen; Pieter Buma; Jeroen Kuipers; Dirk W Grijpma; Arjan Vissink; Ruud R M Bos; Baucke van Minnen Journal: Bioact Mater Date: 2022-01-19
Authors: Constantin Landes; Alexander Ballon; Shahram Ghanaati; Daniel Ebel; Dieter Ulrich; Uwe Spohn; Ute Heunemann; Robert Sader; Raimund Jaeger Journal: Open Biomed Eng J Date: 2013-11-29