Shunji Suzuki1, Sayaka Okudaira. 1. Department of Obstetrics and Gynecology, Tokyo Rinkai Hospital, 1-4-2 Rinkai-cho, 134-0086 Edogawa-ku, Tokyo, Japan. czg83542@mopera.ne.jp
Abstract
INTRODUCTION: This study investigated the T helper Th1:Th2 balance in twin pregnancies compared with singleton pregnancies during the first trimester. METHODS: Blood samples were taken from 24 women with a singleton pregnancy and 14 women with twin pregnancy at 8-9 weeks' gestation to examine the ratios of Th1:Th2 and serum human chorionic gonadotropin (hCG) and progesterone levels. RESULTS: The average ratio of Th1:Th2 in the twin pregnancies was significantly lower than that in singleton pregnancies (7.3+/-2.3 vs. 10.5+/-2.2, p<0.05). There were negative correlations between the Th1:Th2 ratio and serum hCG levels (mIU/ml) (Th1:Th2 ratio = 14.5-4.52 x 10(-5)xhCG, r(2)=0.41, p<0.05) and between the Th1:Th2 ratio and serum progesterone levels (ng/dl; Th1:Th2 ratio = 23.0-0.63 x progesterone, r(2)=0.36, p<0.05). CONCLUSION: Our findings show marked predominance of Th2 type cytokines occurring in twin pregnancies is related to the increase in trophoblasts during the first trimester.
INTRODUCTION: This study investigated the T helper Th1:Th2 balance in twin pregnancies compared with singleton pregnancies during the first trimester. METHODS: Blood samples were taken from 24 women with a singleton pregnancy and 14 women with twin pregnancy at 8-9 weeks' gestation to examine the ratios of Th1:Th2 and serum human chorionic gonadotropin (hCG) and progesterone levels. RESULTS: The average ratio of Th1:Th2 in the twin pregnancies was significantly lower than that in singleton pregnancies (7.3+/-2.3 vs. 10.5+/-2.2, p<0.05). There were negative correlations between the Th1:Th2 ratio and serum hCG levels (mIU/ml) (Th1:Th2 ratio = 14.5-4.52 x 10(-5)xhCG, r(2)=0.41, p<0.05) and between the Th1:Th2 ratio and serum progesterone levels (ng/dl; Th1:Th2 ratio = 23.0-0.63 x progesterone, r(2)=0.36, p<0.05). CONCLUSION: Our findings show marked predominance of Th2 type cytokines occurring in twin pregnancies is related to the increase in trophoblasts during the first trimester.
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