Literature DB >> 14551348

Kidney transplants, antibodies and rejection: is C4d a magic marker?

Volker Nickeleit1, Michael J Mihatsch.   

Abstract

The immunohistochemical detection of the complement degradation product C4d in renal allograft biopsies has gained considerable clinical interest in recent years. The accumulation of C4d along peritubular capillaries is generally regarded as a marker for an antibody-mediated allo-response and is associated with poor graft survival. The aim of this review is to discuss histological findings associated with the deposition of C4d. Emphasis is placed on diagnostic and therapeutic implications. Unanswered questions regarding C4d and graft injury are highlighted.

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Year:  2003        PMID： 14551348     DOI： 10.1093/ndt/gfg304

Source DB:  PubMed          Journal:  Nephrol Dial Transplant        ISSN： 0931-0509            Impact factor:   5.992


  24 in total

Review 1.  [Alloantibodies-mediated kidney transplant rejection: a pair of continuing approaches, and with nonetheless many open questions].

Authors:  Georg Böhmig
Journal:  Wien Klin Wochenschr       Date:  2006-07       Impact factor: 1.704

2.  Could the complement component C4 or its fragment C4d be a marker of the more severe conditions in patients with primary Sjögren's syndrome?

Authors:  Gintaras Sudzius; Diana Mieliauskaite; Almantas Siaurys; Rita Viliene; Irena Butrimiene; Dainius Characiejus; Irena Dumalakiene
Journal:  Rheumatol Int       Date:  2013-10-29       Impact factor: 2.631

3.  Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes.

Authors:  Maarten Naesens; Purvesh Khatri; Li Li; Tara K Sigdel; Matthew J Vitalone; Rong Chen; Atul J Butte; Oscar Salvatierra; Minnie M Sarwal
Journal:  Kidney Int       Date:  2011-08-31       Impact factor: 10.612

Review 4.  Sensitive solid-phase detection of donor-specific antibodies as an aid highly relevant to improving allograft outcomes.

Authors:  Gerald Schlaf; Beatrix Pollok-Kopp; Wolfgang W Altermann
Journal:  Mol Diagn Ther       Date:  2014-04       Impact factor: 4.074

5.  Predominance of intraglomerular T-bet or GATA3 may determine mechanism of transplant rejection.

Authors:  Qiquan Sun; Dongrui Cheng; Mingchao Zhang; Qunpeng He; Zhaohong Chen; Zhihong Liu
Journal:  J Am Soc Nephrol       Date:  2011-02       Impact factor: 10.121

Review 6.  Pros and cons for C4d as a biomarker.

Authors:  Danielle Cohen; Robert B Colvin; Mohamed R Daha; Cinthia B Drachenberg; Mark Haas; Volker Nickeleit; Jane E Salmon; Banu Sis; Ming-Hui Zhao; Jan A Bruijn; Ingeborg M Bajema
Journal:  Kidney Int       Date:  2012-02-01       Impact factor: 10.612

7.  Portal capillary C4d deposits and increased infiltration by macrophages indicate humorally mediated mechanisms in acute cellular liver allograft rejection.

Authors:  Anja Dankof; Maximilian Schmeding; Lars Morawietz; Raphaela Günther; Manfred G Krukemeyer; Birgit Rudolph; Martin Koch; Veit Krenn; Ulf Neumann
Journal:  Virchows Arch       Date:  2005-06-10       Impact factor: 4.064

8.  Evaluation of Renal Allograft Biopsies for Graft Dysfunction and Relevance of C4d Staining in Antibody Mediated Rejection.

Authors:  Clement Wilfred Devadass; Aruna Vishwanth Vanikar; Lovelesh Kumar Nigam; Kamal Vinod Kanodia; Rashmi Dalsukhbhai Patel; Kyasakkala Sannaboraiah Vinay; Himanshu V Patel
Journal:  J Clin Diagn Res       Date:  2016-03-01

9.  Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long-Term Outcomes.

Authors:  B D Modena; S M Kurian; L W Gaber; J Waalen; A I Su; T Gelbart; T S Mondala; S R Head; S Papp; R Heilman; J J Friedewald; S M Flechner; C L Marsh; R S Sung; H Shidban; L Chan; M M Abecassis; D R Salomon
Journal:  Am J Transplant       Date:  2016-03-15       Impact factor: 8.086

10.  Role of the receptor for the globular domain of C1q protein in the pathogenesis of hepatitis C virus-related cryoglobulin vascular damage.

Authors:  Domenico Sansonno; Felicia Anna Tucci; Berhane Ghebrehiwet; Gianfranco Lauletta; Ellinor I B Peerschke; Vincenza Conteduca; Sabino Russi; Pietro Gatti; Loredana Sansonno; Franco Dammacco
Journal:  J Immunol       Date:  2009-10-14       Impact factor: 5.422
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