| Literature DB >> 14550952 |
Yoshihiro Nishioka1, Satoru Sagae, Akira Nishikawa, Shin ichi Ishioka, Ryuichi Kudo.
Abstract
Single nucleotide polymorphism (SNP) of the promoter region of MMP-1 (at -1607 bp) creates Ets binding sites, and correlations between this SNP and cancer susceptibility have been reported for various cancers. In this study, we genotyped the SNP in 23 cervical intraepithelial neoplasias (CIN) and 86 cervical cancer specimens. We found a correlation between promoter polymorphism and MMP-1 expression, and that this SNP was correlated with the clinical stage of cervical cancer. These findings suggested that SNP of MMP-1 promoter might influence the ability in cervical cancer invasion via transcriptional activity of this gene.Entities:
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Year: 2003 PMID： 14550952 DOI： 10.1016/s0304-3835(03)00411-7
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679