| Literature DB >> 14550951 |
Hester van der Woude1, Anna Gliszczyńska-Swigło, Karin Struijs, Astrid Smeets, Gerrit M Alink, Ivonne M C M Rietjens.
Abstract
Optimal in vitro conditions regarding quercetin solubility and stability were defined. Using these conditions, the effect of quercetin on proliferation of the colon carcinoma cell lines HCT-116 and HT29 and the mammary adenocarcinoma cell line MCF-7 was investigated. For the colon carcinoma cell lines, at relatively high concentrations, a significant decrease in cell proliferation was observed, providing a basis for claims on the anti-carcinogenic activity of quercetin. However, at lower concentrations, a subtle but significant stimulation of cell proliferation was observed for all cell lines tested. These results point at a dualistic influence of quercetin on cell proliferation that may affect present views on its supposed beneficial anti-proliferative effect.Entities:
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Year: 2003 PMID： 14550951 DOI： 10.1016/s0304-3835(03)00412-9
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679