Literature DB >> 14550568

Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?

Fiona A Barry1, Gwenda J Graham, Michael J Fry, Jonathan M Gibbins.   

Abstract

In this study we show that both glycogen synthase kinase 3 (GSK3) isoforms, GSK3alpha and GSK3beta, are present in human platelets and are phosphorylated on Ser(21) and Ser(9), respectively, in platelets stimulated with collagen, convulxin and thrombin. Phosphorylation of GSK3alpha/beta was dependent on phosphoinositide 3-kinase (PI3K) activity and independent of platelet aggregation, and correlated with a decrease in GSK3 activity that was preserved by pre-incubating platelets with PI3K inhibitor LY294002. Three structurally distinct GSK3 inhibitors, lithium, SB415286 and TDZD-8, were found to inhibit platelet aggregation. This implicates GSK3 as a potential regulator of platelet function.

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Year:  2003        PMID： 14550568     DOI： 10.1016/s0014-5793(03)01015-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  20 in total

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Review 2.  Platelet biomarkers in Alzheimer's disease.

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Authors:  Brian M Steele; Matthew T Harper; Iain C Macaulay; Craig N Morrell; Alita Perez-Tamayo; Martina Foy; Raymond Habas; Alastair W Poole; Desmond J Fitzgerald; Patricia B Maguire
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-09       Impact factor: 11.205

5.  An important role for Akt3 in platelet activation and thrombosis.

Authors:  Kelly A O'Brien; Aleksandra Stojanovic-Terpo; Nissim Hay; Xiaoping Du
Journal:  Blood       Date:  2011-08-05       Impact factor: 22.113

6.  Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals.

Authors:  Donna C Davidson; Michael P Hirschman; Sherry L Spinelli; Craig N Morrell; Giovanni Schifitto; Richard P Phipps; Sanjay B Maggirwar
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7.  Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase-3beta.

Authors:  Brendan J R Whittle; Csaba Varga; Anikó Pósa; Andor Molnár; Marika Collin; Christoph Thiemermann
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8.  GSK3beta is a negative regulator of platelet function and thrombosis.

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Journal:  Blood       Date:  2008-01-24       Impact factor: 22.113

9.  Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth.

Authors:  Yves Jossin; André M Goffinet
Journal:  Mol Cell Biol       Date:  2007-08-13       Impact factor: 4.272

10.  The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function.

Authors:  Francisca C Gushiken; Han Hyojeong; Subhashree Pradhan; Kimberly W Langlois; Nawaf Alrehani; Miguel A Cruz; Rolando E Rumbaut; K Vinod Vijayan
Journal:  PLoS One       Date:  2009-12-15       Impact factor: 3.240
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