Literature DB >> 14544533

High-level expression of foreign genes in Hansenula polymorpha.

G Gellissen1, Z A Janowicz, U Weydemann, K Melber, A W Strasser, C P Hollenberg.   

Abstract

The methylotrophic yeast Hansenula polymorpha belongs to a limited number of non-Saccharomyces yeast species used as hosts for heterologous gene expression. It has successfully been applied for the production of hormones, antigens and enzymes. The system excells by mitotically stable recombinant strains, high productivity and faithful processing of the produced polypeptides. The favourable characteristics of this microorganism for protein production at an industrial scale are described in the following article focusing on some recent representative examples.

Entities:  

Year:  1992        PMID： 14544533     DOI： 10.1016/0734-9750(92)90002-q

Source DB:  PubMed          Journal:  Biotechnol Adv        ISSN： 0734-9750            Impact factor:   14.227


  7 in total

1.  Comparison of two hepatitis B vaccines (GeneVac-B and Engerix-B) in healthy infants in India.

Authors:  Virbhadra Somani; B S Srikanth; M Mohan; P S Kulkarni
Journal:  Clin Vaccine Immunol       Date:  2006-06

2.  Generation of hepatitis B virus PreS2-S antigen in Hansenula polymorpha.

Authors:  Xiaowei Xu; Sulin Ren; Xiaoxiao Chen; Jun Ge; Zhenxing Xu; Hongying Huang; Honglin Sun; Yue Gu; Tong Zhou; Jianqiang Li; Hanmei Xu
Journal:  Virol Sin       Date:  2014-12-24       Impact factor: 4.327

3.  Interference of humic acids and DNA extracted directly from soil in detection and transformation of recombinant DNA from bacteria and a yeast.

Authors:  C C Tebbe; W Vahjen
Journal:  Appl Environ Microbiol       Date:  1993-08       Impact factor: 4.792

4.  High-level secretion of hirudin by Hansenula polymorpha--authentic processing of three different preprohirudins.

Authors:  U Weydemann; P Keup; M Piontek; A W Strasser; J Schweden; G Gellissen; Z A Janowicz
Journal:  Appl Microbiol Biotechnol       Date:  1995-12       Impact factor: 4.813

5.  Direct detection of recombinant gene expression by two genetically engineered yeasts in soil on the transcriptional and translational levels.

Authors:  C C Tebbe; D F Wenderoth; W Vahjen; K Lübke; J C Munch
Journal:  Appl Environ Microbiol       Date:  1995-12       Impact factor: 4.792

Review 6.  The Challenges of Recombinant Endostatin in Clinical Application: Focus on the Different Expression Systems and Molecular Bioengineering.

Authors:  Abbas Mohajeri; Sarvin Sanaei; Farhad Kiafar; Amir Fattahi; Majid Khalili; Nosratollah Zarghami
Journal:  Adv Pharm Bull       Date:  2017-04-13

7.  Expression of recombinant staphylokinase in the methylotrophic yeast Hansenula polymorpha.

Authors:  Manal Moussa; Mahmoud Ibrahim; Maria El Ghazaly; Jan Rohde; Stefan Gnoth; Andreas Anton; Frank Kensy; Frank Mueller
Journal:  BMC Biotechnol       Date:  2012-12-19       Impact factor: 2.563
  7 in total

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